Pre_GI: BLASTP Hits

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Query: NC_010520:121077:140752 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 140752, End: 141519, Length: 768

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012658:125500:144410144410145177768Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein9e-139492
NC_009698:120119:139773139773140540768Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein2e-137487
NC_009697:120117:139771139771140538768Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein2e-137487
NC_009495:128000:146968146968147735768Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein2e-137487
NC_012563:122000:140904140904141671768Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein4e-137487
NC_017297:122383:142041142041142808768Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein8e-137486
NC_009699:122000:141777141777142544768Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein8e-137486
NC_010516:127000:146761146761147528768Clostridium botulinum B1 str. Okra, complete genomehypothetical protein8e-132469
NC_008593:2250871:226472522647252265537813Clostridium novyi NT, complete genomespore coat protein,putative5e-38157