Pre_GI: BLASTP Hits

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Query: NC_010520:121077:134312 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 134312, End: 135058, Length: 747

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012658:125500:137970137970138716747Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein1e-136485
NC_017297:122383:135599135599136345747Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-136484
NC_009699:122000:135334135334136080747Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein2e-136484
NC_012563:122000:134461134461135207747Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein2e-136484
NC_010516:127000:140318140318141064747Clostridium botulinum B1 str. Okra, complete genomehypothetical protein5e-136483
NC_009495:128000:140525140525141271747Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein1e-135482
NC_009697:120117:133328133328134074747Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein1e-135482
NC_009698:120119:133330133330134076747Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein1e-135482
NC_007503:1111457:114209611420961142857762Carboxydothermus hydrogenoformans Z-2901, complete genomehypothetical protein4e-90331
NC_019978:315346:321890321890322657768Halobacteroides halobius DSM 5150, complete genomeNCAIR mutase-like protein3e-83308
NC_015565:2027279:205331520533152054064750Desulfotomaculum carboxydivorans CO-1-SRB chromosome, complete1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase7e-82303
NC_014624:1369642:137785313778531378602750Eubacterium limosum KIST612 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase2e-81301
NC_011297:1357947:137070513707051371463759Dictyoglomus thermophilum H-6-12, complete genomecircadian phase modifier CpmA4e-75281
NC_011661:1542335:155508715550871555845759Dictyoglomus turgidum DSM 6724, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase9e-74276
NC_015388:1161740:116489911648991165651753Desulfobacca acetoxidans DSM 11109 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase6e-72270
NC_014507:1127115:113860211386021139357756Methanoplanus petrolearius DSM 11571 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase2e-66252
NC_016023:1874827:188179318817931882548756Bacillus coagulans 36D1 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase6e-66250
NC_006510:1995916:200719220071922008001810Geobacillus kaustophilus HTA426, complete genomehypothetical protein9e-66249
NC_014206:1618988:163087216308721631681810Geobacillus sp. C56-T3 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase2e-65248
NC_014216:608740:615153615153615908756Desulfurivibrio alkaliphilus AHT2 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase4e-58224
NC_006576:414696:418696418696419478783Synechococcus elongatus PCC 6301, complete genomecircadian phase modifier CpmA3e-51202
NC_007604:1183497:120132712013271202109783Synechococcus elongatus PCC 7942, complete genomecircadian phase modifier CpmA2e-51202
NC_009975:1565865:156586515658651566632768Methanococcus maripaludis C6, complete genomeconserved hypothetical protein3e-46185
NC_015320:1342105:137331213733121374040729Archaeoglobus veneficus SNP6 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase3e-45181
NC_015574:2322811:232821923282192328974756Methanobacterium sp. SWAN-1 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase1e-44179
NC_009634:349204:369651369651370418768Methanococcus vannielii SB chromosome, complete genomehypothetical protein3e-42171
NC_014122:939190:942984942984943766783Methanocaldococcus infernus ME chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase2e-41169
NC_013156:182896:182121182121182939819Methanocaldococcus fervens AG86, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase2e-40166
NC_008553:1717000:173707517370751737863789Methanosaeta thermophila PT, complete genomephosphoribosylaminoimidazole carboxylase related protein1e-38159
NC_009051:1588060:158806015880601588797738Methanoculleus marisnigri JR1, complete genomeAIR carboxylase6e-38157
NC_009486:1737703:179106917910691791824756Thermotoga petrophila RKU-1 chromosome, complete genomeNCAIR mutase (PurE)-like protein7e-37154
NC_015416:1542202:154376315437631544602840Methanosaeta concilii GP-6 chromosome, complete genomehypothetical protein4e-35148
NC_014002:809816:828170828170828985816Methanohalophilus mahii DSM 5219 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase1e-33143
NC_007355:923218:923218923218924024807Methanosarcina barkeri str. fusaro chromosome 1, complete sequenceAIR carboxylase9e-33140
NC_013158:2303000:230415823041582304931774Halorhabdus utahensis DSM 12940, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase5e-31134
NC_009615:3818500:383660138366013837107507Parabacteroides distasonis ATCC 8503 chromosome, complete genomephosphoribosylaminoimidazole carboxylase catalytic subunit PurE1e-0653.5
NC_015562:1460124:148780114878011488274474Methanotorris igneus Kol 5 chromosome, complete genomephosphoribosylaminoimidazole carboxylase, catalytic subunit2e-0653.1
NC_019977:728922:729810729810730196387Methanomethylovorans hollandica DSM 15978, complete genomephosphoribosylcarboxyaminoimidazole (NCAIR) mutase3e-0652.4
NC_013156:182896:207982207982208458477Methanocaldococcus fervens AG86, complete genomephosphoribosylaminoimidazole carboxylase, catalytic subunit3e-0652
NC_015389:2030154:207051620705162070989474Coriobacterium glomerans PW2 chromosome, complete genome5-(carboxyamino)imidazole ribonucleotide mutase4e-0651.6