Pre_GI: BLASTP Hits

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Query: NC_010516:583870:600549 Clostridium botulinum B1 str. Okra, complete genome

Start: 600549, End: 601565, Length: 1017

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:564455:5837725837725847881017Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein0665
NC_014328:938393:9506969506969517481053Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein4e-38159
NC_008262:2169262:2172445217244521734941050Clostridium perfringens SM101, complete genomehypothetical protein6e-37154
NC_003366:2286083:2289285228928522903341050Clostridium perfringens str. 13, complete genomehypothetical protein5e-36152
NC_008261:2481500:2503141250314125041901050Clostridium perfringens ATCC 13124, complete genomehypothetical protein9e-36150
NC_014410:2511753:2511753251175325127781026Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,hypothetical protein8e-31134
NC_010723:915697:9378849378849389211038Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein2e-24113
NC_015499:1062359:1067558106755810685621005Thermodesulfobium narugense DSM 14796 chromosome, complete genomehypothetical protein4e-2099
NC_015873:238187:239035239035239937903Megasphaera elsdenii DSM 20460, complete genomehypothetical protein4e-0859.3