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Query: NC_010516:359310:378478 Clostridium botulinum B1 str. Okra, complete genome

Start: 378478, End: 378897, Length: 420

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012034:438000:440670440670441101432Anaerocellum thermophilum DSM 6725, complete genomeGtrA family protein2e-1788.2
NC_014392:412916:416740416740417207468Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomeGtrA family protein4e-1683.2
NC_015949:2101302:212537621253762125843468Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomeGtrA family protein3e-1580.5
NC_014721:373607:373153373153373620468Caldicellulosiruptor kristjanssonii 177R1B chromosome, completegtra family protein3e-1580.5
NC_009667:2860818:288085828808582881247390Ochrobactrum anthropi ATCC 49188 chromosome 1, complete sequenceGtrA family protein1e-0652
NC_014650:1410790:143159314315931432015423Geobacillus sp. Y4.1MC1 chromosome, complete genomeGtrA family protein3e-0650.4
NC_014376:597000:624677624677625165489Clostridium saccharolyticum WM1 chromosome, complete genomeGtrA family protein5e-0649.7
NC_015572:1252000:1318976131897613203281353Methylomonas methanica MC09 chromosome, complete genomefamily 2 glycosyl transferase7e-0649.3