Pre_GI: BLASTP Hits

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Query: NC_010516:3368951:3377658 Clostridium botulinum B1 str. Okra, complete genome

Start: 3377658, End: 3378671, Length: 1014

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012658:3387774:3395422339542233964351014Clostridium botulinum Ba4 str. 657 chromosome, complete genomedehydrogenase0671
NC_012563:3556763:3559159355915935601721014Clostridium botulinum A2 str. Kyoto, complete genomedehydrogenase, FMN-dependent0667
NC_009697:3291500:3293017329301732940301014Clostridium botulinum A str. ATCC 19397 chromosome, completedehydrogenase, FMN-dependent0664
NC_009495:3309550:3317028331702833180411014Clostridium botulinum A str. ATCC 3502 chromosome, complete genomedehydrogenase, FMN-dependent0664
NC_009698:3185359:3190124319012431911371014Clostridium botulinum A str. Hall chromosome, complete genomedehydrogenase, FMN-dependent0662
NC_014328:3747973:3754411375441137554271017Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative FMN-dependent alpha-hydroxy acid dehydrogenase3e-166584
NC_003366:2143173:2153614215361421546361023Clostridium perfringens str. 13, complete genomeprobable glycolate oxidase3e-135481
NC_008262:2025699:2037558203755820385801023Clostridium perfringens SM101, complete genomehydroxyacid oxidase 21e-134479
NC_015565:2027279:2078924207892420799431020Desulfotomaculum carboxydivorans CO-1-SRB chromosome, complete(S)-2-hydroxy-acid oxidase8e-116416
NC_013385:1064188:1086930108693010879491020Ammonifex degensii KC4, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase3e-110398
NC_013173:2261396:2269518226951822705341017Desulfomicrobium baculatum DSM 4028, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase1e-98359
NC_015589:2878000:2894051289405128950731023Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase6e-97354
NC_014150:2617072:2623245262324526242581014Brachyspira murdochii DSM 12563 chromosome, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase5e-86318
NC_012225:2834642:2840533284053328415461014Brachyspira hyodysenteriae WA1, complete genomeFMN-dependent alpha-hydroxyacid oxidizing enzyme1e-85317
NC_019908:1467000:1487172148717214881851014Brachyspira pilosicoli P43/6/78 chromosome, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase4e-83308
NC_018607:2375344:2394891239489123959041014Brachyspira pilosicoli B2904 chromosome, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase5e-83308
NC_015873:380485:4018204018204028541035Megasphaera elsdenii DSM 20460, complete genomedehydrogenase3e-67255
NC_013730:2187898:2194127219412721951761050Spirosoma linguale DSM 74, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase3e-36152
NC_018866:1279000:127900012790001279929930Dehalobacter sp. DCA chromosome, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase4e-33142
NC_018867:1357540:135754013575401358469930Dehalobacter sp. CF chromosome, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase4e-33142
NC_017187:691769:7003927003927014681077Arcobacter butzleri ED-1, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase2e-33142
NC_012721:182965:2045582045582056761119Burkholderia glumae BGR1 chromosome 2, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase8e-31134
NC_015385:351393:368592368592369443852Treponema succinifaciens DSM 2489 chromosome, complete genomehypothetical protein2e-30133
NC_012917:4646491:4660211466021146613711161Pectobacterium carotovorum subsp. carotovorum PC1, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase1e-29130
NC_003047:2477810:2483254248325424843481095Sinorhizobium meliloti 1021, complete genomePUTATIVE L-LACTATE DEHYDROGENASE (CYTOCHROME) PROTEIN1e-29130
NC_015590:2290359:2295803229580322968971095Sinorhizobium meliloti AK83 chromosome 1, complete sequence(S)-2-hydroxy-acid oxidase1e-29130
NC_017322:2191391:2196835219683521979291095Sinorhizobium meliloti BL225C chromosome, complete genome(S)-2-hydroxy-acid oxidase1e-29130
NC_017325:967598:9849539849539860471095Sinorhizobium meliloti SM11 chromosome, complete genome(S)-2-hydroxy-acid oxidase1e-29130
NC_004547:138500:1402681402681414281161Erwinia carotovora subsp. atroseptica SCRI1043, complete genomeL-lactate dehydrogenase4e-29128
NC_010322:5293652:5293652529365252947971146Pseudomonas putida GB-1 chromosome, complete genomeL-lactate dehydrogenase1e-28127
NC_010501:734363:7661877661877673321146Pseudomonas putida W619, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase2e-28126
NC_008027:775896:7964437964437975881146Pseudomonas entomophila L48, complete genomeL-lactate dehydrogenase, FMN linked3e-28125
NC_013501:1691532:1709845170984517110351191Rhodothermus marinus DSM 4252, complete genomeLactate 2-monooxygenase1e-27124
NC_012721:137046:1455441455441467071164Burkholderia glumae BGR1 chromosome 2, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase5e-27122
NC_014311:1309562:1327676132767613288271152Ralstonia solanacearum PSI07 chromosome, complete genomeL-lactate dehydrogenase, FMN-linked4e-27122
NC_007606:3755155:3775620377562037768101191Shigella dysenteriae Sd197, complete genomeL-lactate dehydrogenase3e-27122
NC_004337:3590323:3752425375242537536151191Shigella flexneri 2a str. 301, complete genomeL-lactate dehydrogenase3e-27122
NC_012759:3648500:3666176366617636673661191Escherichia coli BW2952 chromosome, complete genomeL-lactate dehydrogenase3e-27122
NC_008253:3941938:3966658396665839678871230Escherichia coli 536, complete genomeputative FMN-dependent dehydrogenase7e-26118
NC_007946:4779745:4807909480790948091261218Escherichia coli UTI89, complete genomeputative FMN-dependent dehydrogenase1e-25117
NC_015514:3307199:3340787334078733419981212Cellulomonas fimi ATCC 484 chromosome, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase6e-25115
NC_012660:4734363:4747036474703647481931158Pseudomonas fluorescens SBW25 chromosome, complete genomeL-lactate dehydrogenase5e-25115
NC_020126:3383902:3387540338754033887631224Myxococcus stipitatus DSM 14675, complete genome(S)-2-hydroxy-acid oxidase4e-25115
NC_007963:1190847:1214439121443912156381200Chromohalobacter salexigens DSM 3043, complete genome(S)-2-hydroxy-acid oxidase7e-25114
NC_012984:3077004:3096118309611830972181101Lactobacillus plantarum JDM1, complete genomelactate oxidase1e-24114
NC_014323:245979:2489332489332501741242Herbaspirillum seropedicae SmR1 chromosome, complete genomeFMN-dependent L-lactate dehydrogenase3e-24112
NC_018643:1309804:1315929131592913170801152Alpha proteobacterium HIMB5 chromosome, complete genomedehydrogenase, FMN-dependent8e-24111
NC_018644:516157:5186995186995198561158Alpha proteobacterium HIMB59 chromosome, complete genomedehydrogenase, FMN-dependent6e-23108
NC_012125:2143246:2169433216943321706381206Salmonella enterica subsp. enterica serovar Paratyphi C strainglycolate oxidase2e-22107
NC_020995:2636519:2640621264062126417241104Enterococcus casseliflavus EC20, complete genomeL-lactate oxidase1e-22107
NC_010102:1388344:1414521141452114157231203Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein1e-22107
NC_003198:1378457:1396641139664113978431203Salmonella enterica subsp. enterica serovar Typhi str. CT18,putative glycolate oxidase1e-22107
NC_011035:1033942:1045422104542210465941173Neisseria gonorrhoeae NCCP11945 chromosome, complete genomeputative L-lactate dehydrogenase7e-22105
NC_017511:950411:9612479612479624191173Neisseria gonorrhoeae TCDC-NG08107 chromosome, complete genomeputative L-lactate dehydrogenase7e-22105
NC_002946:618439:6259916259916271631173Neisseria gonorrhoeae FA 1090, complete genomeputative L-lactate dehydrogenase6e-22105
NC_010677:1621500:1657548165754816587051158Francisella tularensis subsp. mediasiatica FSC147, complete genomeL-lactate dehydrogenase6e-22105
NC_013199:2386924:2393109239310923942241116Lactobacillus rhamnosus Lc 705, complete genomeL-lactate dehydrogenase (FMN-dependent) related alpha-hydroxy acid dehydrogenase3e-22105
NC_017516:917817:9255519255519267111161Neisseria meningitidis H44/76 chromosome, complete genomeL-lactate dehydrogenase1e-21104
NC_017517:1377617:1389198138919813903581161Neisseria meningitidis M01-240355 chromosome, complete genomeL-lactate dehydrogenase1e-21104
NC_013016:1257942:1271346127134612725871242Neisseria meningitidis alpha14 chromosome, complete genomeL-lactate dehydrogenase1e-21104
NC_013850:2182337:2182337218233721835211185Klebsiella variicola At-22 chromosome, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase9e-22104
NC_003116:1488576:1499437149943715006091173Neisseria meningitidis Z2491, complete genomeL-lactate dehydrogenase9e-22104
NC_017505:1338661:1351557135155713527291173Neisseria meningitidis alpha710 chromosome, complete genomeL-lactate dehydrogenase9e-22104
NC_017512:1264542:1275403127540312765751173Neisseria meningitidis WUE 2594, complete genomeL-lactate dehydrogenase (cytochrome)9e-22104
NC_010999:2483000:2485994248599424871091116Lactobacillus casei, complete genomeNAD-independent L-lactate dehydrogenase1e-21103
NC_009257:963536:9773809773809785221143Francisella tularensis subsp. tularensis WY96-3418 chromosome,L-lactate dehydrogenase9e-21101
NC_007880:935670:9382129382129393811170Francisella tularensis subsp. holarctica, complete genomeL-lactate dehydrogenase2e-20100
NC_008369:939356:942179942179943066888Francisella tularensis subsp. holarctica OSU18, complete genomeL-lactate dehydrogenase (cytochrome)2e-20100
NC_008314:477722:5187525187525198971146Ralstonia eutropha H16 chromosome 2, complete sequenceL-Lactate cytochrome reductase1e-20100
NC_009749:937412:9399549399549411231170Francisella tularensis subsp. holarctica FTA, complete genomeL-lactate dehydrogenase2e-2099.8
NC_010505:2690939:2704608270460827057531146Methylobacterium radiotolerans JCM 2831, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase3e-2099.4
NC_011205:1633353:1659562165956216606981137Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853L-lactate oxidase3e-1996.3
NC_017186:2252438:2255591225559122568021212Amycolatopsis mediterranei S699 chromosome, complete genomeL-lactate dehydrogenase4e-1995.9
NC_014318:2252417:2255570225557022567811212Amycolatopsis mediterranei U32 chromosome, complete genomeL-lactate dehydrogenase4e-1995.9
NC_008025:669281:6713996713996726701272Deinococcus geothermalis DSM 11300, complete genomeLactate 2-monooxygenase4e-1995.5
NC_008312:3793760:3834377383437738355341158Trichodesmium erythraeum IMS101, complete genomeL-lactate dehydrogenase (cytochrome)1e-1894.4
NC_014306:2518996:2535516253551625367571242Erwinia billingiae Eb661, complete genomeL-lactate dehydrogenase (Cytochrome)2e-1893.6
NC_006677:1255079:1276029127602912771741146Gluconobacter oxydans 621H, complete genomePutative oxidoreductase2e-1893.2
NC_015703:3842144:3868489386848938696341146Runella slithyformis DSM 19594 chromosome, complete genomeL-lactate dehydrogenase (cytochrome)7e-1891.7
NC_012590:850130:8725578725578738251269Corynebacterium aurimucosum ATCC 700975, complete genomeL-lactate dehydrogenase1e-1790.5
NC_020911:3046916:3063151306315130642961146Octadecabacter antarcticus 307, complete genomecytochrome containing L-lactate dehydrogenase LldD4e-1685.9
NC_014041:3197192:3206232320623232073831152Zunongwangia profunda SM-A87 chromosome, complete genomeL-lactate dehydrogenase and related alpha-hydroxy acid dehydrogenase8e-1684.7
NC_015574:1541613:1553725155372515547801056Methanobacterium sp. SWAN-1 chromosome, complete genomeIsopentenyl-diphosphate delta-isomerase1e-1584
NC_020911:3410857:3428035342803534292191185Octadecabacter antarcticus 307, complete genomeL-lactate dehydrogenase LldD1e-1584
NC_010676:2658495:2664906266490626661141209Burkholderia phytofirmans PsJN chromosome 2, complete sequenceL-lactate dehydrogenase (cytochrome)2e-1583.6
NC_007951:2233676:2234389223438922355791191Burkholderia xenovorans LB400 chromosome 1, complete sequencePutative L-lactate dehydrogenase2e-1480.5
NC_010623:72500:8190181901831001200Burkholderia phymatum STM815 chromosome 2, complete sequenceL-lactate dehydrogenase (cytochrome)5e-1479
NC_005126:1265071:1271090127109012722381149Photorhabdus luminescens subsp. laumondii TTO1, complete genomehypothetical protein3e-1376.3
NC_013947:1570000:1585569158556915865971029Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeFMN-dependent alpha-hydroxy acid dehydrogenase2e-1273.6
NC_017243:1558000:1577367157736715795142148Brachyspira intermedia PWS/A chromosome, complete genomeL-lactate dehydrogenase3e-1273.2
NC_018876:863314:8748438748438759461104Methanolobus psychrophilus R15 chromosome, complete genomeisopentenyl-diphosphate delta-isomerase5e-1272.4
NC_019977:1621939:1627137162713716282671131Methanomethylovorans hollandica DSM 15978, complete genomeisopentenyl-diphosphate delta-isomerase, type 22e-1170.1
NC_007681:979815:9918489918489928971050Methanosphaera stadtmanae DSM 3091, complete genomeisopentenyl-diphosphate delta-isomerase3e-1169.7
NC_007952:3196085:3228502322850232296861185Burkholderia xenovorans LB400 chromosome 2, complete sequenceS-mandelate dehydrogenase (MdlB)4e-1169.3
NC_009515:1409912:1463857146385714649031047Methanobrevibacter smithii ATCC 35061, complete genomeisopentenyl pyrophosphate isomerase8e-1065.1
NC_000909:762859:7853037853037863821080Methanocaldococcus jannaschii DSM 2661, complete genomeisopentenyl pyrophosphate isomerase2e-0963.5
NC_003551:723901:7378727378727389961125Methanopyrus kandleri AV19, complete genomeisopentenyl pyrophosphate isomerase2e-0963.5
NC_014471:163404:1668421668421679841143Ignisphaera aggregans DSM 17230 chromosome, complete genomeisopentenyl-diphosphate delta-isomerase, type 21e-0860.8
NC_014150:3085013:3107308310730831094792172Brachyspira murdochii DSM 12563 chromosome, complete genomeATP-dependent carboxylate-amine ligase domain protein ATP-grasp2e-0860.5
NC_008148:2498000:2515739251573925171211383Rubrobacter xylanophilus DSM 9941, complete genomeferredoxin-dependent glutamate synthase1e-0757.8
NC_014374:318528:3270113270113281441134Acidilobus saccharovorans 345-15 chromosome, complete genomeisopentenyl pyrophosphate isomerase4e-0755.8
NC_015435:120334:1311751311751322751101Metallosphaera cuprina Ar-4 chromosome, complete genomeisopentenyl pyrophosphate isomerase2e-0653.1
NC_008698:235688:2398392398392409241086Thermofilum pendens Hrk 5, complete genomeisopentenyl-diphosphate delta-isomerase, type 24e-0652.8
NC_013790:2690740:2699212269921227006991488Methanobrevibacter ruminantium M1 chromosome, complete genomeglutamate synthase alpha subunit GltA5e-0652
NC_007681:770267:7774067774067788841479Methanosphaera stadtmanae DSM 3091, complete genomeputative glutamate synthase, subunit 2 with ferredoxin domain6e-0652
NC_015931:857327:8670268670268681501125Pyrolobus fumarii 1A, complete genomeisopentenyl-diphosphate delta-isomerase, type 28e-0651.6