Pre_GI: BLASTP Hits

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Query: NC_010418:70000:83424 Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete

Start: 83424, End: 83861, Length: 438

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010418:138325:161763161763162200438Clostridium botulinum A3 str. Loch Maree plasmid pCLK, completephage protein3e-65246
NC_009495:1821938:183625418362541836679426Clostridium botulinum A str. ATCC 3502 chromosome, complete genomephage protein5e-1063.2
NC_014551:576000:584830584830585282453Bacillus amyloliquefaciens DSM 7, complete genomehypothetical protein1e-0858.5
NC_009615:1001744:100619710061971006646450Parabacteroides distasonis ATCC 8503 chromosome, complete genomeprophage Lp2 protein 265e-0650.1