Pre_GI: BLASTP Hits

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Query: NC_010418:70000:72797 Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete

Start: 72797, End: 73531, Length: 735

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018678:1820390:182963818296381830411774Alteromonas macleodii str. 'English Channel 673' chromosome,hypothetical protein1e-59229
NC_009659:1050532:111907111190711119892822Janthinobacterium sp. Marseille chromosome, complete genomehypothetical protein1e-53209
NC_014935:595685:611253611253611963711Nitratifractor saLSUginis DSM 16511 chromosome, complete genomeadenylate/guanylate cyclase6e-43174
NC_003454:63500:649776497765720744Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completehypothetical protein8e-29127
NC_013169:513327:527928527928528353426Kytococcus sedentarius DSM 20547, complete genomehypothetical protein7e-23107