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Query: NC_010161:1811000 Bartonella tribocorum CIP 105476, complete genome

Start: 1811000, End: 1831099, Length: 20100

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_012846:1679184*1679184170209922916Bartonella grahamii as4aup, complete genome03519BLASTN svgBLASTP svg
NC_020301:1449616*1449616147209922484Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genome01435BLASTN svgBLASTP svg
NC_005955:1259393*1259393127892419532Bartonella quintana str. Toulouse, complete genome01368BLASTN svgBLASTP svg
NC_005956:15217361521736154059918864Bartonella henselae str. Houston-1, complete genome01231BLASTN svgBLASTP svg