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Query: NC_010161:596034:614270 Bartonella tribocorum CIP 105476, complete genome

Start: 614270, End: 615490, Length: 1221

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009380:725870:7380917380917393981308Salinispora tropica CNB-440 chromosome, complete genomemajor facilitator transporter3e-0860.1
NC_010617:774914:7827677827677839661200Kocuria rhizophila DC2201, complete genomeMFS transporter3e-0653.5
NC_018681:5695343:5723529572352957247521224Nocardia brasiliensis ATCC 700358 chromosome, complete genomemajor facilitator transporter4e-0652.8
NC_013595:8162181:8195270819527081964901221Streptosporangium roseum DSM 43021, complete genomeantibiotic efflux protein5e-0652.4