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Query: NC_010161:2155500:2186367 Bartonella tribocorum CIP 105476, complete genome

Start: 2186367, End: 2187518, Length: 1152

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012846:1778443:1794271179427117968732603Bartonella grahamii as4aup, complete genome4e-48192
NC_012846:2004711:2021623202162320227831161Bartonella grahamii as4aup, complete genomehypothetical protein9e-162570
NC_012846:1952178:1966010196601019686222613Bartonella grahamii as4aup, complete genomehypothetical protein3e-47189
NC_005956:1648000:167139916713991671683285Bartonella henselae str. Houston-1, complete genomehypothetical protein4e-0962.8
NC_010161:1368500:1368607136860713711712565Bartonella tribocorum CIP 105476, complete genomehypothetical protein1e-41171
NC_010161:432000:4520474520474546112565Bartonella tribocorum CIP 105476, complete genomehypothetical protein9e-42171