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Query: NC_010161:2155500:2168831 Bartonella tribocorum CIP 105476, complete genome

Start: 2168831, End: 2169898, Length: 1068

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008570:2216736:223452922345292235266738Aeromonas hydrophila subsp. hydrophila ATCC 7966, complete genomehypothetical protein3e-0653.1
NC_008783:177161:1967971967971978131017Bartonella bacilliformis KC583, complete genomehypothetical protein8e-78290
NC_014932:1314881:134203813420381342910873Bartonella clarridgeiae 73, complete genomehypothetical protein2e-73276
NC_012846:2004711:2010633201063320117031071Bartonella grahamii as4aup, complete genomephage related protein6e-150530
NC_005956:1648000:165665016566501657579930Bartonella henselae str. Houston-1, complete genomehypothetical protein7e-94344
NC_005956:1648000:165757616575761657869294Bartonella henselae str. Houston-1, complete genomehypothetical protein1e-1170.9
NC_005956:1648000:1657853165785316589981146Bartonella henselae str. Houston-1, complete genomehypothetical protein7e-1891.7
NC_010805:1642978:165001916500191650825807Burkholderia multivorans ATCC 17616 chromosome 2, completebacteriophage protein4e-0652.8
NC_010086:810890:824479824479825285807Burkholderia multivorans ATCC 17616 chromosome 2, completehypothetical protein4e-0652.8
NC_010002:2110953:212490021249002125676777Delftia acidovorans SPH-1, complete genomehypothetical protein5e-0652.4
NC_019907:845663:866345866345867118774Liberibacter crescens BT-1 chromosome, complete genomehypothetical protein3e-0963.2
NC_009720:4033983:403947340394734040324852Xanthobacter autotrophicus Py2, complete genomehypothetical protein1e-0757.4
NC_010577:1188438:121235612123561213243888Xylella fastidiosa M23, complete genomeprotein of unknown function DUF13763e-1066.6
NC_004556:1178897:120281612028161203721906Xylella fastidiosa Temecula1, complete genomehypothetical protein3e-1066.6