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Query: NC_010161:2155500:2168113 Bartonella tribocorum CIP 105476, complete genome

Start: 2168113, End: 2168430, Length: 318

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012846:2004711:200989920098992010216318Bartonella grahamii as4aup, complete genomehypothetical protein3e-48190
NC_005956:1648000:165577816557781656095318Bartonella henselae str. Houston-1, complete genomehypothetical protein1e-44178
NC_014932:1314881:134129213412921341609318Bartonella clarridgeiae 73, complete genomehypothetical protein3e-42170
NC_008783:177161:198720198720199034315Bartonella bacilliformis KC583, complete genomehypothetical protein2e-40164
NC_016642:4517478:452852145285214528814294Pseudovibrio sp. FO-BEG1 chromosome, complete genomehelix-turn-helix type 3 domain-containing protein3e-0960.5
NC_014387:177308:180159180159180521363Butyrivibrio proteoclasticus B316 chromosome 1, complete genomeHTH domain-containing protein2e-0858.2
NC_012781:1968827:199127319912731991599327Eubacterium rectale ATCC 33656, complete genomehypothetical protein2e-0651.2