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Query: NC_010161:2155500:2164217 Bartonella tribocorum CIP 105476, complete genome

Start: 2164217, End: 2165008, Length: 792

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012846:2004711:200751120075112008254744Bartonella grahamii as4aup, complete genomephage related exonuclease8e-121432
NC_005956:1648000:165259616525961653312717Bartonella henselae str. Houston-1, complete genomephage related protein3e-103374
NC_008783:177161:200489200489201226738Bartonella bacilliformis KC583, complete genomeputative exonuclease1e-93342
NC_014932:1314881:133953913395391340156618Bartonella clarridgeiae 73, complete genomePhage related protein5e-92337
NC_009720:4087831:408827140882714088900630Xanthobacter autotrophicus Py2, complete genomehypothetical protein9e-48190
NC_015733:2720183:275328527532852753902618Pseudomonas putida S16 chromosome, complete genomeexonuclease, phage-type1e-37156
NC_009428:1827352:186029018602901860928639Rhodobacter sphaeroides ATCC 17025 chromosome, complete genomehypothetical protein2e-35149
NC_014910:1708045:171601617160161716663648Alicycliphilus denitrificans BC chromosome, complete genomeyqaj viral recombinase family8e-23107
NC_013174:2321000:233121523312152331892678Jonesia denitrificans DSM 20603, complete genomehypothetical protein1e-20100
NC_010002:2110953:211577421157742116403630Delftia acidovorans SPH-1, complete genomeExonuclease, phage-type3e-2099
NC_015379:4691868:469908546990854699753669Pseudomonas brassicacearum subsp. brassicacearum NFM421 chromosome,Putative phage exonuclease7e-1994.4
NC_016845:1285435:129162912916291292252624Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,putative phage-like protein9e-1684
NC_017986:4931104:495419549541954954962768Pseudomonas putida ND6 chromosome, complete genomehypothetical protein2e-1583.2
NC_020418:3133831:314345531434553144051597Morganella morganii subsp. morganii KT, complete genomeexonuclease6e-1271.2
NC_011001:1145508:114689511468951147575681Burkholderia cenocepacia J2315 chromosome 2, complete sequencehypothetical protein2e-0859.7
NC_002927:2338549:234032623403262340973648Bordetella bronchiseptica RB50, complete genomephage-related exonuclease8e-0857.8