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Query: NC_010161:205500:205592 Bartonella tribocorum CIP 105476, complete genome

Start: 205592, End: 206371, Length: 780

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012846:1708840:172809417280941728873780Bartonella grahamii as4aup, complete genomephage related protein4e-127453
NC_012846:1952178:195217819521781953011834Bartonella grahamii as4aup, complete genomephage related protein4e-40164
NC_012846:986877:986877986877987710834Bartonella grahamii as4aup, complete genomephage related protein4e-40164
NC_012846:1708840:172648817264881727321834Bartonella grahamii as4aup, complete genomephage related protein4e-40164
NC_012846:1778443:177844317784431779276834Bartonella grahamii as4aup, complete genomephage related protein4e-40164
NC_012846:1708840:172739917273991727983585Bartonella grahamii as4aup, complete genomephage related protein1e-33143
NC_012985:1191125:122234512223451222677333Candidatus Liberibacter asiaticus str. psy62, complete genomeintrrupted gp229, phage associated protein3e-0652.8
NC_014774:171500:197629197629198198570Candidatus Liberibacter solanacearum CLso-ZC1 chromosome, completehypothetical protein7e-27120
NC_013235:464049:484400484400485149750Nakamurella multipartita DSM 44233, complete genomehypothetical protein1e-0963.5
NC_010067:3538169:354388635438863544521636Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein5e-1478.2