Pre_GI: BLASTP Hits

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Query: NC_010161:1949637:1973207 Bartonella tribocorum CIP 105476, complete genome

Start: 1973207, End: 1976725, Length: 3519

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005956:1455496:1463064146306414690906027Bartonella henselae str. Houston-1, complete genomeProbable surface protein9e-111402
NC_010161:1914000:1918359191835919215473189Bartonella tribocorum CIP 105476, complete genomeautotransporter3e-110400
NC_010161:1914000:1914499191449919171832685Bartonella tribocorum CIP 105476, complete genomeputative autotransporter3e-108394
NC_012846:1837924:1841926184192618450303105Bartonella grahamii as4aup, complete genomeautotransporter1e-107391
NC_012846:1837924:1845735184573518521546420Bartonella grahamii as4aup, complete genomeautotransporter3e-107390
NC_010161:1914000:1922216192221619287916576Bartonella tribocorum CIP 105476, complete genomeautotransporter3e-107390
NC_020300:1274581:1290349129034912933633015Bartonella australis Aust/NH1, complete genomeautotransporter7e-105382
NC_005955:1205836:1210540121054012135753036Bartonella quintana str. Toulouse, complete genomehypothetical protein3e-104380
NC_005955:1205836:1214203121420312198215619Bartonella quintana str. Toulouse, complete genomeProbable surface protein4e-104380
NC_020300:1274581:1287217128721712901892973Bartonella australis Aust/NH1, complete genomeautotransporter2e-98361
NC_014932:1084422:1086453108645310894613009Bartonella clarridgeiae 73, complete genomehypothetical protein7e-98359
NC_020300:1274581:1280918128091812838182901Bartonella australis Aust/NH1, complete genomeautotransporter7e-98359
NC_020300:1274581:1283988128398812870233036Bartonella australis Aust/NH1, complete genomeautotransporter1e-96355
NC_020300:1274581:1277908127790812807482841Bartonella australis Aust/NH1, complete genomeautotransporter1e-95352
NC_012846:1837924:1837924183792418407642841Bartonella grahamii as4aup, complete genomeautotransporter9e-76286
NC_005956:1455496:145928514592851459866582Bartonella henselae str. Houston-1, complete genomeProbable surface protein5e-49197
NC_005956:1455496:1459863145986314623462484Bartonella henselae str. Houston-1, complete genomehypothetical protein1e-47192
NC_020418:116500:1173911173911202552865Morganella morganii subsp. morganii KT, complete genomePutative adhesion and penetration protein5e-0654.3