Pre_GI: BLASTP Hits

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Query: NC_010161:1949637:1971308 Bartonella tribocorum CIP 105476, complete genome

Start: 1971308, End: 1971793, Length: 486

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010161:1324381:134590913459091346379471Bartonella tribocorum CIP 105476, complete genomeputative phage tail protein1e-67254
NC_010161:1914000:193530519353051935775471Bartonella tribocorum CIP 105476, complete genomeputative phage tail protein1e-67254
NC_012846:1837924:185904118590411859502462Bartonella grahamii as4aup, complete genomephage tail protein U55e-56216
NC_015856:1182974:118820811882081188765558Collimonas fungivorans Ter331 chromosome, complete genomephage p2 GpU2e-0651.6
NC_003198:4453457:44737534473753450773033978Salmonella enterica subsp. enterica serovar Typhi str. CT18,4e-0650.8
NC_003198:4453457:447582044758204476305486Salmonella enterica subsp. enterica serovar Typhi str. CT18,putative phage tail protein5e-0650.4