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Query: NC_010161:1949637:1971057 Bartonella tribocorum CIP 105476, complete genome

Start: 1971057, End: 1971311, Length: 255

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010161:1914000:193505419350541935308255Bartonella tribocorum CIP 105476, complete genomehypothetical protein2e-42170
NC_010161:1324381:134565813456581345912255Bartonella tribocorum CIP 105476, complete genomehypothetical protein2e-42170
NC_020301:669000:697954697954698208255Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomephage tail protein X3e-34143
NC_012846:1837924:185879018587901859044255Bartonella grahamii as4aup, complete genomephage tail protein X56e-32135