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Query: NC_010161:1949637:1968069 Bartonella tribocorum CIP 105476, complete genome

Start: 1968069, End: 1968620, Length: 552

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010161:1324381:134252113425211343051531Bartonella tribocorum CIP 105476, complete genomehypothetical protein3e-77287
NC_010161:1501758:151989815198981520428531Bartonella tribocorum CIP 105476, complete genomehypothetical protein3e-77287
NC_010161:2548254:256632025663202566850531Bartonella tribocorum CIP 105476, complete genomehypothetical protein1e-68258
NC_005956:1019788:102049510204951020779285Bartonella henselae str. Houston-1, complete genomehypothetical genomic island protein4e-27120
NC_020301:853267:857051857051857413363Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomehypothetical protein2e-2098.6
NC_011989:2549252:255180625518062552465660Agrobacterium vitis S4 chromosome 1, complete sequencetranscriptional regulator9e-1476.6
NC_005956:1455496:147318414731841473395212Bartonella henselae str. Houston-1, complete genome8e-1166.6
NC_016629:2784000:281421828142182814973756Desulfovibrio africanus str. Walvis Bay chromosome, completePeptidase S24/S26A/S26B, conserved region3e-0754.7