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Query: NC_010161:1179000:1191315 Bartonella tribocorum CIP 105476, complete genome

Start: 1191315, End: 1191683, Length: 369

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012846:1147000:116125611612561161624369Bartonella grahamii as4aup, complete genomeputative transcriptional regulator3e-41166
NC_017248:264847:273215273215273571357Brucella melitensis NI chromosome chromosome I, complete sequencehypothetical protein3e-21100
NC_015857:265721:274006274006274362357Brucella pinnipedialis B2/94 chromosome chromosome 1, completehypothetical protein3e-21100
NC_006932:266000:274246274246274602357Brucella abortus biovar 1 str. 9-941 chromosome I, completehypothetical protein3e-21100
NC_009505:264963:273170273170273526357Brucella ovis ATCC 25840 chromosome I, complete sequencehypothetical protein3e-21100
NC_005956:1019788:102160110216011021909309Bartonella henselae str. Houston-1, complete genomehypothetical genomic island protein3e-1373.9
NC_017177:91993:953399533995698360Clostridium difficile BI1, complete genomeXRE family transcriptional regulator3e-1063.5
NC_008380:4968492:4976721497672149777851065Rhizobium leguminosarum bv. viciae 3841, complete genomehypothetical protein6e-1062.8
NC_014628:319222:323516323516323917402Paenibacillus polymyxa SC2 plasmid pSC2, complete sequenceXRE family, bacteriophage lambda repressor C1 like protein2e-0858.2
NC_015500:2329957:236242223624222362820399Treponema brennaborense DSM 12168 chromosome, complete genomehelix-turn-helix domain protein1e-0652.4