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Query: NC_010161:1179000:1184262 Bartonella tribocorum CIP 105476, complete genome

Start: 1184262, End: 1184378, Length: 117

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010161:2235500:2245926224592622469391014Bartonella tribocorum CIP 105476, complete genomehypothetical protein5e-1269.7
NC_012846:986877:1013486101348610144991014Bartonella grahamii as4aup, complete genomeputative phage tail fiber protein3e-0857
NC_010161:2235500:2246948224694822479491002Bartonella tribocorum CIP 105476, complete genomehypothetical protein1e-0755.1
NC_010161:1179000:1183252118325211842531002Bartonella tribocorum CIP 105476, complete genomehypothetical protein1e-0755.1
NC_012846:986877:1012476101247610134771002Bartonella grahamii as4aup, complete genomeputative phage tail fiber protein2e-0651.2
NC_012846:986877:1014507101450710156341128Bartonella grahamii as4aup, complete genomeputative phage tail fiber protein4e-0650.4
NC_005956:1019788:102551310255131026493981Bartonella henselae str. Houston-1, complete genomePhage related protein4e-0650.4
NC_008783:222000:237453237453238424972Bartonella bacilliformis KC583, complete genomehypothetical protein3e-0650.4
NC_010161:2235500:2244788224478822459181131Bartonella tribocorum CIP 105476, complete genomehypothetical protein4e-0650.1
NC_010161:1179000:1185282118528211864121131Bartonella tribocorum CIP 105476, complete genomephage related protein5e-0650.1