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Query: NC_010161:1179000:1181479 Bartonella tribocorum CIP 105476, complete genome

Start: 1181479, End: 1181679, Length: 201

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012846:986877:100501610050161005216201Bartonella grahamii as4aup, complete genomehypothetical DNA-binding protein3e-32136
NC_012846:929570:945941945941946141201Bartonella grahamii as4aup, complete genomehypothetical DNA-binding protein3e-32136
NC_003047:536151:543112543112543309198Sinorhizobium meliloti 1021, complete genomehypothetical protein2e-1477.8
NC_016795:9384:318753187532093219Brucella abortus A13334 chromosome 1, complete sequencetranscriptional regulator2e-1270.9
NC_012587:128845:139552139552139749198Rhizobium sp. NGR234, complete genomehypothetical protein3e-1270.5
NC_015590:145353:149157149157149354198Sinorhizobium meliloti AK83 chromosome 1, complete sequencehypothetical protein3e-1270.5
NC_003317:1719546:174205017420501742268219Brucella melitensis 16M chromosome I, complete sequencehypothetical protein1e-1168.9