Pre_GI: BLASTP Hits

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Query: NC_010161:1179000:1179092 Bartonella tribocorum CIP 105476, complete genome

Start: 1179092, End: 1179493, Length: 402

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003317:1719546:1739125173912517406541530Brucella melitensis 16M chromosome I, complete sequenceHypothetical Membrane Spanning Protein7e-26115
NC_016795:9384:289512895129268318Brucella abortus A13334 chromosome 1, complete sequencehypothetical protein2e-1684.3
NC_013722:2150882:2178543217854321806332091Xanthomonas albilineans, complete genomehypothetical protein6e-1476.3
NC_020054:4161049:4182495418249541841261632Fibrella aestuarina BUZ 2 drat genomehypothetical protein1e-0858.2