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Query: NC_010117:980313 Coxiella burnetii RSA 331, complete genome

Start: 980313, End: 999098, Length: 18786

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain (RSA 331; Hentzerling) is associated with acute Q fever and was isolated from the blood of an infected patient in northern Italy in 1945. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_002971:78050278050280263022129Coxiella burnetii RSA 493, complete genome022860BLASTN svgBLASTP svg
NC_011528:64740164740166974422344Coxiella burnetii CbuK_Q154, complete genome022560BLASTN svgBLASTP svg
NC_011527:11132171113217113200418788Coxiella burnetii CbuG_Q212, complete genome022560BLASTN svgBLASTP svg
NC_012793:3275751*3275751330479129041Geobacillus sp. WCH70, complete genome6e-1383.8BLASTN svgBLASTP svg
NC_009832:2969376*2969376299269223317Serratia proteamaculans 568, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_007575:19209519209521009918005Sulfurimonas denitrificans DSM 1251, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_012691:31265003126500315237825879Tolumonas auensis DSM 9187, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_009648:26997392699739273776838030Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_008343:823093*82309385175828666Granulibacter bethesdensis CGDNIH1, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_014121:33996853399685343519435510Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, complete1e-0765.9BLASTN svgBLASTP svg
NC_020260:1535394*1535394155809922706Cronobacter sakazakii Sp291, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_013508:1289159*1289159133392244764Edwardsiella tarda EIB202, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_009778:14778411477841150009922259Enterobacter sakazakii ATCC BAA-894, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_008700:2701500*2701500273890037401Shewanella amazonensis SB2B, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_011146:1998981*1998981205724258262Geobacter bemidjiensis Bem, complete genome9e-0660BLASTN svgBLASTP svg
NC_008577:49074974907497493408326587Shewanella sp. ANA-3 chromosome 1, complete sequence9e-0660BLASTN svgBLASTP svg