Pre_GI: BLASTP Hits

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Query: NC_009882:563830:581550 Rickettsia rickettsii str. 'Sheila Smith', complete genome

Start: 581550, End: 581855, Length: 306

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from from a patient with Rocky Mountain spotted fever. Causative agent for Rocky Mountain Spotted Fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Rickettsia rickettsii was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:563941:581660581660581965306Rickettsia rickettsii str. Hino chromosome, complete genomeseptum formation initiator5e-52202
NC_016911:563822:581541581541581846306Rickettsia rickettsii str. Hauke chromosome, complete genomeseptum formation initiator5e-52202
NC_016909:563727:581446581446581751306Rickettsia rickettsii str. Arizona chromosome, complete genomeseptum formation initiator5e-52202
NC_016908:563747:581467581467581772306Rickettsia rickettsii str. Colombia chromosome, complete genomeseptum formation initiator5e-52202
NC_010263:563814:581533581533581838306Rickettsia rickettsii str. Iowa, complete genomeseptum formation initiator5e-52202
NC_017044:564000:582010582010582315306Rickettsia parkeri str. Portsmouth chromosome, complete genomeseptum formation initiator1e-50198
NC_003103:563961:577074577074577379306Rickettsia conorii str. Malish 7, complete genomehypothetical protein7e-51198
NC_009881:562000:578038578038578361324Rickettsia akari str. Hartford, complete genomehypothetical protein5e-50196
NC_017058:862000:864810864810865133324Rickettsia australis str. Cutlack chromosome, complete genomeseptum formation initiator2e-49194
NC_009879:670169:671688671688672023336Rickettsia canadensis str. McKiel, complete genomehypothetical protein1e-48191
NC_016929:657451:661120661120661455336Rickettsia canadensis str. CA410 chromosome, complete genomeseptum formation initiator1e-48191
NC_017051:505000:519692519692520015324Rickettsia prowazekii str. Dachau chromosome, complete genomeseptum formation initiator5e-47186
NC_000963:506500:521565521565521888324Rickettsia prowazekii str. Madrid E, complete genomehypothetical protein5e-47186
NC_017057:507500:521769521769522110342Rickettsia prowazekii str. RpGvF24 chromosome, complete genomeseptum formation initiator6e-47185
NC_017056:506500:521547521547521888342Rickettsia prowazekii str. BuV67-CWPP chromosome, complete genomeseptum formation initiator6e-47185
NC_017050:506500:521568521568521909342Rickettsia prowazekii str. Katsinyian chromosome, complete genomeseptum formation initiator6e-47185
NC_017049:505000:519682519682520023342Rickettsia prowazekii str. Chernikova chromosome, complete genomeseptum formation initiator6e-47185
NC_017048:849000:863704863704864045342Rickettsia prowazekii str. GvV257 chromosome, complete genomeseptum formation initiator6e-47185
NC_017062:508500:522714522714523037324Rickettsia typhi str. B9991CWPP chromosome, complete genomeseptum formation initiator1e-45181