Pre_GI: BLASTP Hits

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Query: NC_009882:563830:565725 Rickettsia rickettsii str. 'Sheila Smith', complete genome

Start: 565725, End: 565901, Length: 177

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from from a patient with Rocky Mountain spotted fever. Causative agent for Rocky Mountain Spotted Fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Rickettsia rickettsii was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:563941:565836565836566012177Rickettsia rickettsii str. Hino chromosome, complete genomeacriflavin resistance periplasmic protein1e-25115
NC_016911:563822:565717565717565893177Rickettsia rickettsii str. Hauke chromosome, complete genomeacriflavin resistance periplasmic protein1e-25115
NC_016909:563727:565622565622565798177Rickettsia rickettsii str. Arizona chromosome, complete genomeacriflavin resistance periplasmic protein1e-25115
NC_016908:563747:565642565642565818177Rickettsia rickettsii str. Colombia chromosome, complete genomeacriflavin resistance periplasmic protein1e-25115
NC_010263:563814:565709565709565885177Rickettsia rickettsii str. Iowa, complete genomeacriflavin resistance periplasmic protein1e-25115
NC_017044:564000:566141566141566359219Rickettsia parkeri str. Portsmouth chromosome, complete genomehypothetical protein1e-23108
NC_017058:862000:880381880381880578198Rickettsia australis str. Cutlack chromosome, complete genomeRND family transporter membrane-fusion protein6e-1579.3
NC_009881:562000:563292563292563489198Rickettsia akari str. Hartford, complete genomeMembrane-fusion protein component of the RND family transporter2e-1374.3