Pre_GI: BLASTP Hits

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Query: NC_009882:167350:170459 Rickettsia rickettsii str. 'Sheila Smith', complete genome

Start: 170459, End: 170836, Length: 378

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from from a patient with Rocky Mountain spotted fever. Causative agent for Rocky Mountain Spotted Fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Rickettsia rickettsii was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016930:165376:168493168493168870378Rickettsia philipii str. 364D chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein4e-58222
NC_010263:167450:170552170552170929378Rickettsia rickettsii str. Iowa, complete genomesuccinate dehydrogenase membrane anchor subunit4e-58222
NC_016908:167423:170532170532170909378Rickettsia rickettsii str. Colombia chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein4e-58222
NC_016911:167398:170500170500170877378Rickettsia rickettsii str. Hauke chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein4e-58222
NC_016914:167537:170639170639171016378Rickettsia rickettsii str. Hino chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein4e-58222
NC_016915:162841:170725170725171102378Rickettsia rickettsii str. Hlp#2 chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein4e-58222
NC_003103:164972:168113168113168493381Rickettsia conorii str. Malish 7, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein [EC:1.3.99.1]6e-55212
NC_007109:1206421:123488912348891235251363Rickettsia felis URRWXCal2, complete genomeSuccinate dehydrogenase hydrophobic membrane anchor protein3e-54209
NC_000963:141500:149933149933150310378Rickettsia prowazekii str. Madrid E, complete genomeSUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN (sdhD)5e-50196
NC_017048:484000:492097492097492474378Rickettsia prowazekii str. GvV257 chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein5e-50196
NC_017049:140000:148132148132148509378Rickettsia prowazekii str. Chernikova chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein5e-50196
NC_017050:141500:149931149931150308378Rickettsia prowazekii str. Katsinyian chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein5e-50196
NC_017051:140000:148136148136148513378Rickettsia prowazekii str. Dachau chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein5e-50196
NC_017056:141500:149941149941150318378Rickettsia prowazekii str. BuV67-CWPP chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein5e-50196
NC_017057:142000:150153150153150530378Rickettsia prowazekii str. RpGvF24 chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein5e-50196
NC_009881:166500:174409174409174786378Rickettsia akari str. Hartford, complete genomeSuccinate dehydrogenase hydrophobic membrane anchor protein6e-50195
NC_006142:140853:150470150470150847378Rickettsia typhi str. Wilmington, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein1e-48191
NC_017062:141270:150887150887151264378Rickettsia typhi str. B9991CWPP chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein1e-48191
NC_017066:140853:150470150470150847378Rickettsia typhi str. TH1527 chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein1e-48191
NC_009879:141000:149004149004149381378Rickettsia canadensis str. McKiel, complete genomehypothetical protein3e-48189
NC_016929:141972:149976149976150353378Rickettsia canadensis str. CA410 chromosome, complete genomesuccinate dehydrogenase hydrophobic membrane anchor protein3e-48189
NC_009883:277409:280599280599280976378Rickettsia bellii OSU 85-389, complete genomeSuccinate dehydrogenase hydrophobic membrane anchor protein4e-45179