Pre_GI: BLASTN Hits

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Query: NC_009727:670616 Coxiella burnetii Dugway 7E9-12, complete genome

Start: 670616, End: 693340, Length: 22725

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_009712:18223751822375185409931725Candidatus Methanoregula boonei 6A8, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_011527:12559981255998129002234025Coxiella burnetii CbuG_Q212, complete genome042730BLASTN svgBLASTP svg
NC_011528:14920001492000152159929600Coxiella burnetii CbuK_Q154, complete genome034720BLASTN svgBLASTP svg
NC_010117:70011270011272771927608Coxiella burnetii RSA 331, complete genome042740BLASTN svgBLASTP svg
NC_002971:61935561935564709927745Coxiella burnetii RSA 493, complete genome042880BLASTN svgBLASTP svg