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Query: NC_009727:1678568 Coxiella burnetii Dugway 7E9-12, complete genome

Start: 1678568, End: 1699099, Length: 20532

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_007626:3996000*3996000401964723648Magnetospirillum magneticum AMB-1, complete genome8e-25123BLASTN svgBLASTP svg
NC_009727:1899876*1899876192060720732Coxiella burnetii Dugway 7E9-12, complete genome1e-23119BLASTN svgBLASTP svg
NC_008344:811386*81138684559634211Nitrosomonas eutropha C91, complete genome5e-20107BLASTN svgBLASTP svg
NC_015422:910292*91029293677826487Alicycliphilus denitrificans K601 chromosome, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_014910:966761*96676199256725807Alicycliphilus denitrificans BC chromosome, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_010804:450130*45013047811127982Burkholderia multivorans ATCC 17616 chromosome 1, complete3e-1591.7BLASTN svgBLASTP svg
NC_009074:3409849*3409849344201632168Burkholderia pseudomallei 668 chromosome I, complete sequence3e-1591.7BLASTN svgBLASTP svg
NC_008782:867344*86734489009922756Acidovorax sp. JS42, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_014532:349384*34938437223122848Halomonas elongata DSM 2581, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_018868:1352000*1352000138222930230Simiduia agarivorans SA1 = DSM 21679 chromosome, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_014973:1257625*1257625128014722523Geobacter sp. M18 chromosome, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_010338:1394550*1394550141650721958Caulobacter sp. K31, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_007908:1328832*1328832136532136490Rhodoferax ferrireducens T118, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_007513:1900000*1900000192383823839Synechococcus sp. CC9902, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_008782:84113484113486233621203Acidovorax sp. JS42, complete genome1e-0560BLASTN svgBLASTP svg
NC_004337:3590323*35903233952993362671Shigella flexneri 2a str. 301, complete genome1e-0560BLASTN svgBLASTP svg
NC_002939:1926084*1926084196150735424Geobacter sulfurreducens PCA, complete genome1e-0560BLASTN svgBLASTP svg