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Query: NC_009727:357206:374133 Coxiella burnetii Dugway 7E9-12, complete genome

Start: 374133, End: 374678, Length: 546

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010117:1633447:163344716334471633992546Coxiella burnetii RSA 331, complete genomeopacity family porin protein2e-98357
NC_002971:1545924:154606515460651546610546Coxiella burnetii RSA 493, complete genomehypothetical protein2e-98357
NC_002939:805794:823097823097823771675Geobacter sulfurreducens PCA, complete genometia invasion determinant-related protein5e-1167.4
NC_010102:2762304:276668727666872767406720Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein2e-0755.5
NC_012125:326909:344411344411345130720Salmonella enterica subsp. enterica serovar Paratyphi C strainouter membrane adhesin4e-0754.7
NC_011294:311796:329433329433330152720Salmonella enterica subsp. enterica serovar Enteritidis strouter membrane adhesin5e-0753.9
NC_011083:338910:357912357912358631720Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,hypothetical protein5e-0753.9
NC_003197:332086:349893349893350612720Salmonella typhimurium LT2, complete genomeSapA-like protein5e-0753.9
NC_011149:309556:332595332595333254660Salmonella enterica subsp. enterica serovar Agona str. SL483,putative outer membrane adhesin6e-0753.9
NC_016810:329849:349371349371350090720Salmonella enterica subsp. enterica serovar Typhimurium strouter membrane adhesin5e-0753.9
NC_016831:2667561:267378826737882674507720Salmonella enterica subsp. enterica serovar Gallinarum/pullorumputative outer membrane adhesin5e-0753.9
NC_016856:332771:350578350578351297720Salmonella enterica subsp. enterica serovar Typhimurium str. 14028SSapA-like protein5e-0753.9
NC_016857:329849:349371349371350090720Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74SapA-like protein5e-0753.9
NC_016860:332087:349894349894350613720Salmonella enterica subsp. enterica serovar Typhimurium strputative outer membrane adhesin5e-0753.9
NC_016863:332060:349867349867350586720Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1SapA-like protein5e-0753.9
NC_017046:329847:349369349369350088720Salmonella enterica subsp. enterica serovar Typhimurium str. 798outer membrane adhesin5e-0753.9
NC_011080:333121:354407354407355126720Salmonella enterica subsp. enterica serovar Newport str. SL254,putative outer membrane adhesin7e-0753.5
NC_006511:2540500:254581325458132546532720Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCCpossible outer membrane adhesin7e-0753.5
NC_011147:2536000:254134925413492542068720Salmonella enterica subsp. enterica serovar Paratyphi A strouter membrane adhesin7e-0753.5
NC_016832:2612809:261798926179892618708720Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,outer membrane adhesin2e-0652
NC_004631:2615908:262108826210882621807720Salmonella enterica subsp. enterica serovar Typhi Ty2, completepossible outer membrane adhesin2e-0652
NC_011750:4775770:479414647941464794901756Escherichia coli IAI39 chromosome, complete genomeTia invasion determinant9e-0649.7