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Query: NC_009727:357206:373290 Coxiella burnetii Dugway 7E9-12, complete genome

Start: 373290, End: 373712, Length: 423

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002971:1545924:154694115469411547426486Coxiella burnetii RSA 493, complete genomehypothetical protein3e-78289
NC_010117:1633447:163438616343861634808423Coxiella burnetii RSA 331, complete genome1e-77288
NC_011528:1769349:177027717702771770762486Coxiella burnetii CbuK_Q154, complete genomehypothetical protein1e-77287
NC_010995:1459831:146131514613151461782468Cellvibrio japonicus Ueda107, complete genomepossible ribosomal protein S6 modification protein1e-37155
NC_019940:3863124:386264938626493863155507Thioflavicoccus mobilis 8321 chromosome, complete genomehypothetical protein3e-36150
NC_007954:3171081:317108131710813171512432Shewanella denitrificans OS217, complete genomeprotein of unknown function DUF7857e-34142
NC_012803:2454380:247115924711592471689531Micrococcus luteus NCTC 2665, complete genomehypothetical protein5e-28122
NC_009092:4337617:436844543684454368870426Shewanella loihica PV-4, complete genomeprotein of unknown function DUF7856e-28122
NC_005773:5684000:568531656853165685792477Pseudomonas syringae pv. phaseolicola 1448A, complete genomepossible ribosomal protein S6 modification protein2e-27121
NC_013222:432947:4329474329474343201374Robiginitalea biformata HTCC2501, complete genomepossible ribosomal protein S6 modification protein1e-25114
NC_017506:1785872:179645217964521797051600Marinobacter adhaerens HP15 chromosome, complete genomehypothetical protein5e-1269.7
NC_019940:1727384:175339817533981754045648Thioflavicoccus mobilis 8321 chromosome, complete genomehypothetical protein9e-1165.5
NC_015638:923660:939712939712940137426Lacinutrix sp. 5H-3-7-4 chromosome, complete genomehypothetical protein1e-0962
NC_011901:3072817:307657130765713077089519Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, completehypothetical protein2e-0857.8
NC_005140:960261:977166977166977783618Vibrio vulnificus YJ016 chromosome II, complete sequencehypothetical protein6e-0856.2
NC_013037:3994083:401247440124744012932459Dyadobacter fermentans DSM 18053, complete genomeprotein of unknown function DUF7852e-0754.7
NC_009850:2169459:218907921890792189501423Arcobacter butzleri RM4018, complete genomeconserved hypothetical protein (DUF785 domain protein)5e-0753.1