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Query: NC_009727:1177390:1190939 Coxiella burnetii Dugway 7E9-12, complete genome

Start: 1190939, End: 1191226, Length: 288

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010681:1234500:125690612569061257235330Burkholderia phytofirmans PsJN chromosome 1, complete sequenceExcinuclease ABC C subunit domain protein9e-0958.9
NC_008260:2142311:215805421580542158443390Alcanivorax borkumensis SK2, complete genomehypothetical protein1e-0755.1
NC_010723:298954:317452317452317709258Clostridium botulinum E3 str. Alaska E43, complete genomeGIY-YIG domain protein8e-0752.4
NC_010674:311378:323994323994324251258Clostridium botulinum B str. Eklund 17B, complete genomeGIY-YIG domain protein2e-0650.8
NC_019908:700000:711532711532711867336Brachyspira pilosicoli P43/6/78 chromosome, complete genomeexcinuclease ABC subunit C2e-0650.8
NC_014330:2520906:252882225288222529157336Brachyspira pilosicoli 95/1000 chromosome, complete genomeputative excinuclease ABC subunit C3e-0650.8
NC_018604:1489567:149822214982221498557336Brachyspira pilosicoli WesB complete genomeputative excinuclease ABC subunit C3e-0650.8
NC_018607:1251357:126050312605031260778276Brachyspira pilosicoli B2904 chromosome, complete genomeendonuclease containing a URI domain3e-0650.4
NC_007759:1028977:107141610714161071679264Syntrophus aciditrophicus SB, complete genomepredicted endonuclease containing a URI domain5e-0649.7