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Query: NC_009727:1177390:1189755 Coxiella burnetii Dugway 7E9-12, complete genome

Start: 1189755, End: 1190957, Length: 1203

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016616:1091606:1093534109353410947721239Dechlorosoma suillum PS chromosome, complete genomemembrane-bound lytic murein transglycosylase8e-66251
NC_007614:2764848:2794097279409727952901194Nitrosospira multiformis ATCC 25196 chromosome 1, completeMltA1e-65251
NC_012559:2663747:2711678271167827128441167Laribacter hongkongensis HLHK9, complete genomeMembrane-bound lytic murein transglycosylase7e-62238
NC_009850:2169459:2192344219234421934321089Arcobacter butzleri RM4018, complete genomepeptidoglycan N-acetylmuramoylhydrolase7e-59228
NC_020209:4312892:4314921431492143161171197Pseudomonas poae RE*1-1-14, complete genometransglycosylase4e-51202
NC_019815:679592:6795926795926808181227Candidatus Kinetoplastibacterium crithidii (ex Angomonas deaneihypothetical protein1e-49197
NC_008044:3024125:3024727302472730257851059Silicibacter sp. TM1040, complete genomeMltA2e-49196
NC_007802:179780:1828511828511838671017Jannaschia sp. CCS1, complete genomeMltA9e-48191
NC_014844:2158318:2159230215923021604981269Desulfovibrio aespoeensis Aspo-2 chromosome, complete genomeMltA domain-containing protein1e-45184
NC_009952:3596399:3627798362779836288261029Dinoroseobacter shibae DFL 12, complete genomemembrane-bound lytic murein transglycosylase A7e-45181
NC_020304:256000:2765392765392777261188Desulfocapsa sulfexigens DSM 10523, complete genomemembrane-bound lytic murein transglycosylase3e-39162
NC_016513:54802:7442474424755421119Aggregatibacter actinomycetemcomitans ANH9381 chromosome, completemurein transglycosyllase A2e-30133
NC_009925:3344894:3359651335965133608291179Acaryochloris marina MBIC11017, complete genomemembrane-bound lytic transglycosylase A, putative1e-29131
NC_013361:3823347:3829123382912338302201098Escherichia coli O26:H11 str. 11368 chromosome, complete genomemurein transglycosylase A1e-27124
NC_011745:3197584:3203360320336032044571098Escherichia coli ED1a chromosome, complete genomemurein transglycosylase A1e-27124
NC_011283:942594:9638899638899649861098Klebsiella pneumoniae 342 chromosome, complete genomemurein transglycosylase A1e-27124
NC_010498:3023442:3029219302921930302861068Escherichia coli SMS-3-5, complete genomemembrane-bound lytic murein transglycosylase A1e-27124
NC_007613:2699500:2702547270254727036441098Shigella boydii Sb227, complete genomemembrane-bound lytic murein transglycosylase A3e-27123
NC_004061:498483:5055935055935066931101Buchnera aphidicola str. Sg (Schizaphis graminum), complete genomemembrane-bound lytic murein transglycosylase9e-27121
NC_017259:480656:4832184832184843001083Buchnera aphidicola str. Ua (Uroleucon ambrosiae) chromosome,murein transglycosylase A2e-26120
NC_016632:398018:3980183980183991781161Serratia symbiotica str. 'Cinara cedri' chromosome, completemembrane-bound lytic murein transglycosylase A4e-26119
NC_003272:637970:6581236581236593161194Nostoc sp. PCC 7120, complete genomehypothetical protein1e-23110
NC_004459:1794540:1799230179923018003331104Vibrio vulnificus CMCP6 chromosome I, complete sequenceMembrane-bound lytic murein transglycosylase9e-23108