Pre_GI: BLASTN Hits

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Query: NC_009699:2056500 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 2056500, End: 2074136, Length: 17637

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_010520:20615022061502208422422723Clostridium botulinum A3 str. Loch Maree, complete genome04540BLASTN svgBLASTP svg
NC_010516:19995001999500201784518346Clostridium botulinum B1 str. Okra, complete genome05364BLASTN svgBLASTP svg
NC_010723:10143341014334103372419391Clostridium botulinum E3 str. Alaska E43, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_011661:10497671049767106859918833Dictyoglomus turgidum DSM 6724, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_014833:3444550*3444550347132026771Ruminococcus albus 7 chromosome, complete genome3e-0867.9BLASTN svgBLASTP svg