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Query: NC_009699:2654672:2676342 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 2676342, End: 2677508, Length: 1167

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018664:1729794:1733089173308917343601272Clostridium acidurici 9a chromosome, complete genomeputative sporulation integral membrane protein2e-27124
NC_015958:1422319:1439956143995614411371182Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomesporulation integral membrane protein YlbJ1e-24114
NC_014964:1309845:1328139132813913293201182Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completesporulation integral membrane protein YlbJ2e-24113
NC_014831:1140356:1141055114105511422631209Thermaerobacter marianensis DSM 12885 chromosome, complete genomesporulation integral membrane protein YlbJ5e-1892.4
NC_013385:90331:1034311034311045401110Ammonifex degensii KC4, complete genomenucleoside recognition domain protein8e-1685.1
NC_014483:1954856:1960805196080519620881284Paenibacillus polymyxa E681 chromosome, complete genomeNucleoside recognition domain protein4e-1479.3
NC_014622:2114244:2120213212021321214961284Paenibacillus polymyxa SC2 chromosome, complete genomefactor required for spore cortex formation4e-1375.9
NC_006177:280234:299955299955300356402Symbiobacterium thermophilum IAM 14863, complete genomehypothetical protein1e-0861.6