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Query: NC_009699:2654672:2662718 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 2662718, End: 2662993, Length: 276

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2635892:266286826628682663143276Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein4e-45179
NC_009698:2450606:245865224586522458927276Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein4e-45179
NC_009697:2478261:248630724863072486582276Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein4e-45179
NC_009495:2606238:261419426141942614469276Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein4e-45179
NC_010520:2668702:267673526767352677010276Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein4e-45179
NC_010516:2594159:260223926022392602514276Clostridium botulinum B1 str. Okra, complete genomehypothetical protein4e-45179
NC_012563:2761570:278856327885632788838276Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein6e-45179
NC_012658:2641446:266962526696252669900276Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein3e-44176
NC_012658:2641446:265408226540822654357276Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein5e-41166
NC_017297:2635892:264468426446842644959276Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-40164
NC_009699:2635745:264453726445372644812276Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein2e-40164
NC_010516:2567911:258406825840682584343276Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-40164
NC_012563:2761570:277036527703652770640276Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein2e-40164
NC_014614:2333890:234223223422322342492261Clostridium sticklandii, complete genomehypothetical protein1e-24111
NC_017179:3621306:362996036299603630244285Clostridium difficile BI1, complete genomehypothetical protein1e-1685.1
NC_013315:3613288:362194236219423622226285Clostridium difficile CD196 chromosome, complete genomehypothetical protein1e-1685.1
NC_009089:3782000:379345837934583793742285Clostridium difficile 630, complete genomehypothetical protein1e-1685.1