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Query: NC_009699:2635745:2639262 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 2639262, End: 2639762, Length: 501

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2635892:263940926394092639909501Clostridium botulinum F str. 230613 chromosome, complete genomeribosomal protein L32 family protein9e-70262
NC_010516:2567911:257879025787902579290501Clostridium botulinum B1 str. Okra, complete genomeribosomal protein L32 family protein1e-69261
NC_012563:2761570:276508727650872765587501Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-69261
NC_012658:2641446:264880726488072649307501Clostridium botulinum Ba4 str. 657 chromosome, complete genomeribosomal protein L32 family protein3e-69260
NC_009698:2420484:243493224349322435432501Clostridium botulinum A str. Hall chromosome, complete genomeribosomal protein L32 family protein4e-69259
NC_010520:2635750:265359226535922654092501Clostridium botulinum A3 str. Loch Maree, complete genomeribosomal protein L32 family protein2e-68257
NC_009495:2571732:259056525905652591064500Clostridium botulinum A str. ATCC 3502 chromosome, complete genome2e-67254
NC_018664:1699618:171652817165281717046519Clostridium acidurici 9a chromosome, complete genomehypothetical protein DUF1772e-1375.5
NC_016048:1930089:196054219605421961030489Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein1e-1168.9
NC_016751:1700164:170844317084431708997555Marinitoga piezophila KA3 chromosome, complete genomehypothetical protein1e-1065.5
NC_007498:1666242:168078016807801681337558Pelobacter carbinolicus DSM 2380, complete genomehypothetical protein2e-1064.7
NC_015958:1422319:143576414357641436249486Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomehypothetical protein7e-1063.2
NC_014964:1309845:132394613239461324431486Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completehypothetical protein7e-1063.2
NC_011661:961129:969050969050969589540Dictyoglomus turgidum DSM 6724, complete genomeprotein of unknown function DUF1772e-0962
NC_013316:1225797:123251612325161233040525Clostridium difficile R20291, complete genomehypothetical protein2e-0961.2
NC_017179:1239991:124467712446771245201525Clostridium difficile BI1, complete genomehypothetical protein3e-0961.2
NC_013315:1230214:123490012349001235424525Clostridium difficile CD196 chromosome, complete genomehypothetical protein3e-0961.2
NC_011297:787932:798201798201798740540Dictyoglomus thermophilum H-6-12, complete genomehypothetical protein5e-0960.5
NC_014831:1140356:115319111531911153811621Thermaerobacter marianensis DSM 12885 chromosome, complete genomeprotein of unknown function DUF1771e-0859.3
NC_014483:1954856:196490019649001965418519Paenibacillus polymyxa E681 chromosome, complete genomePredicted metal-binding, possibly nucleic acid-binding protein2e-0858.5
NC_019978:1410041:142524214252421425712471Halobacteroides halobius DSM 5150, complete genomeputative metal-binding protein, possibly nucleic-acid binding protein3e-0858.2
NC_007517:1792000:179827417982741798813540Geobacter metallireducens GS-15, complete genomeprotein of unknown function DUF1772e-0755.1
NC_014624:2668157:268249026824902682960471Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein4e-0754.3
NC_013939:148706:153005153005153505501Deferribacter desulfuricans SSM1, complete genomehypothetical protein4e-0650.8
NC_014622:2114244:212430021243002124821522Paenibacillus polymyxa SC2 chromosome, complete genomehypothetical protein8e-0649.7
NC_010644:718748:722616722616723095480Elusimicrobium minutum Pei191, complete genomehypothetical protein8e-0649.7