Pre_GI: BLASTP Hits

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Query: NC_009699:2552195:2559860 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 2559860, End: 2560090, Length: 231

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2531750:255999925599992560229231Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-36150
NC_021182:3347076:337153833715383372125588Clostridium pasteurianum BC1, complete genomehypothetical protein7e-1785.9
NC_021182:4367736:437783343778334378420588Clostridium pasteurianum BC1, complete genomehypothetical protein1e-1581.3
NC_014393:4323368:432898743289874329598612Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein2e-1168.2
NC_011899:355638:364178364178364714537Halothermothrix orenii H 168, complete genomehypothetical protein1e-0962
NC_006322:3418268:345721134572113457750540Bacillus licheniformis ATCC 14580, complete genomehypothetical protein1e-0858.9