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Query: NC_009699:2552195:2558468 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 2558468, End: 2559493, Length: 1026

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2531750:2558608255860825596331026Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein0661
NC_012563:2680246:2686417268641726874421026Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-177622
NC_012563:1681639:1696913169691316979621050Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-85317
NC_012658:1405788:1408652140865214097011050Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein8e-85313
NC_009699:3429817:3453755345375534548041050Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein9e-84310
NC_017297:3428429:3452369345236934534181050Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein9e-84310
NC_010516:2676746:2701931270193127029801050Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-83309
NC_020291:5808856:5830296583029658313331038Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein2e-82306
NC_009697:2558286:2583575258357525846241050Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein6e-82304
NC_010418:188138:2012522012522022771026Clostridium botulinum A3 str. Loch Maree plasmid pCLK, completehypothetical protein4e-75281
NC_016012:1312352:1329789132978913308231035Candidatus Arthromitus sp. SFB-rat-Yit, complete genomehypothetical protein1e-44180
NC_017294:1385576:1406295140629514073321038Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomehypothetical protein7e-44177
NC_015913:1422444:1439899143989914409211023Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomehypothetical protein7e-44177
NC_016627:3659500:3660568366056836615931026Clostridium clariflavum DSM 19732 chromosome, complete genomenucleoid-associated protein3e-43175
NC_017179:1133510:1144977114497711459811005Clostridium difficile BI1, complete genomehypothetical protein1e-36154
NC_013315:1123733:1135200113520011362041005Clostridium difficile CD196 chromosome, complete genomehypothetical protein1e-36154
NC_009089:1093832:110417811041781105173996Clostridium difficile 630, complete genomephage protein8e-36151
NC_016894:3329562:3335424333542433364311008Acetobacterium woodii DSM 1030 chromosome, complete genomehypothetical protein9e-2097.8
NC_014828:1795781:180536718053671806356990Ethanoligenens harbinense YUAN-3 chromosome, complete genomehypothetical protein2e-1480.5
NC_014614:2333890:2353835235383523548511017Clostridium sticklandii, complete genomehypothetical protein2e-0757