Pre_GI: BLASTP Hits

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Query: NC_009699:2552195:2553005 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 2553005, End: 2553556, Length: 552

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2531750:255314525531452553696552Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein3e-101367
NC_021182:554000:570188570188570736549Clostridium pasteurianum BC1, complete genomehypothetical protein2e-64244
NC_021182:2536000:255209525520952552643549Clostridium pasteurianum BC1, complete genomehypothetical protein1e-57221
NC_015275:911999:927979927979928527549Clostridium lentocellum DSM 5427 chromosome, complete genomeSigma-70 region 4 type 22e-21102
NC_015275:986382:987572987572988036465Clostridium lentocellum DSM 5427 chromosome, complete genomehypothetical protein3e-1581.6
NC_010723:915697:920387920387920896510Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein2e-1375.5
NC_013315:1679000:169251216925121692991480Clostridium difficile CD196 chromosome, complete genomehypothetical protein3e-1374.3
NC_017179:1683199:170052717005271701006480Clostridium difficile BI1, complete genomehypothetical protein3e-1374.3
NC_011660:2541632:256486625648662565408543Listeria monocytogenes HCC23 chromosome, complete genomehypothetical protein6e-1270.5
NC_010001:986500:100821210082121008709498Clostridium phytofermentans ISDg, complete genomehypothetical protein4e-0754.3
NC_010337:1:417294172942682954Heliobacterium modesticaldum Ice1, complete genomehypothetical protein2e-0652
NC_012563:2680246:268138726813872681866480Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein7e-0650.1