Pre_GI: BLASTP Hits

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Query: NC_009699:2287893:2309999 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 2309999, End: 2311111, Length: 1113

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2288000:2310115231011523112271113Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein0697
NC_009698:2171151:2189641218964121907531113Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein0693
NC_009697:2173000:2189422218942221905341113Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein0693
NC_009495:2244774:2260780226078022618921113Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein0693
NC_012658:2295536:2318150231815023192621113Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein0689
NC_004557:1553000:1566902156690215680171116Clostridium tetani E88, complete genomemembrane spanning protein7e-180629
NC_014328:4316008:4336342433634243374301089Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein2e-141502
NC_010723:1465097:1469850146985014709471098Clostridium botulinum E3 str. Alaska E43, complete genomemembrane spanning protein2e-136485
NC_010674:1496500:1499637149963715007341098Clostridium botulinum B str. Eklund 17B, complete genomemembrane spanning protein1e-135483
NC_009922:2556033:2578350257835025794441095Alkaliphilus oremlandii OhILAs, complete genomeconserved hypothetical protein3e-124445
NC_009633:3933941:3953312395331239544451134Alkaliphilus metalliredigens QYMF chromosome, complete genomemembrane spanning protein3e-121435
NC_014328:4316008:4337882433788243389641083Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein6e-110397
NC_013204:2826500:2852123285212328532321110Eggerthella lenta DSM 2243, complete genomehypothetical protein1e-74280
NC_010001:1745089:1751974175197417529901017Clostridium phytofermentans ISDg, complete genomemembrane spanning protein2e-46186
NC_011883:2826000:2830036283003628310641029Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774,protein of unknown function DUF6 transmembrane8e-2098.2
NC_014363:645397:674033674033674983951Olsenella uli DSM 7084 chromosome, complete genomeprotein of unknown function DUF6 transmembrane5e-1892
NC_003454:1889529:189260218926021893570969Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeCholine transport protein9e-1581.3
NC_008593:1103293:110531811053181106262945Clostridium novyi NT, complete genomelicB protein , putative2e-0963.9