Pre_GI: BLASTP Hits

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Query: NC_009699:2287893:2303558 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 2303558, End: 2304511, Length: 954

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:2384500:239776123977612398714954Clostridium botulinum A2 str. Kyoto, complete genomeglycyl-radical enzyme activating family protein8e-177619
NC_012658:2295536:231172723117272312680954Clostridium botulinum Ba4 str. 657 chromosome, complete genomeglycyl-radical enzyme activating family protein9e-177619
NC_009495:2244774:225435722543572255319963Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeglycyl-radical activating family protein2e-176618
NC_009698:2171151:218321821832182184171954Clostridium botulinum A str. Hall chromosome, complete genomeglycyl-radical enzyme activating family protein3e-176617
NC_009697:2173000:218299921829992183952954Clostridium botulinum A str. ATCC 19397 chromosome, completeglycyl-radical enzyme activating family protein3e-176617
NC_004557:1553000:156226215622621563224963Clostridium tetani E88, complete genomebenzylsuccinate synthase activating enzyme4e-155547
NC_010674:1496500:150598315059831506936954Clostridium botulinum B str. Eklund 17B, complete genomebenzylsuccinate synthase activating enzyme2e-147521
NC_010723:1465097:147619614761961477149954Clostridium botulinum E3 str. Alaska E43, complete genomeglycyl-radical enzyme activating family protein6e-145513
NC_009922:2556033:257209025720902573040951Alkaliphilus oremlandii OhILAs, complete genomeglycyl-radical enzyme activating protein family9e-133473
NC_014328:4316008:432998643299864330936951Clostridium ljungdahlii ATCC 49587 chromosome, complete genomepyruvate formate-lyase activating enzyme3e-131468
NC_010001:1745089:175808817580881759035948Clostridium phytofermentans ISDg, complete genomeglycyl-radical enzyme activating protein family4e-126451
NC_016584:5625975:563927856392785640246969Desulfosporosinus orientis DSM 765 chromosome, complete genomeglycyl-radical enzyme activator family protein8e-111400
NC_009633:3933941:394874939487493949696948Alkaliphilus metalliredigens QYMF chromosome, complete genomeglycyl-radical activating family protein4e-104378
NC_020063:3690308:371903437190343720008975Enterobacteriaceae bacterium strain FGI 57, complete genomeglycyl-radical enzyme activator family protein7e-62237
NC_008563:4707826:472980647298064730723918Escherichia coli APEC O1, complete genomeputative pyruvate-formate lyase-activating enzyme1e-56220
NC_014364:4488875:450773445077344508657924Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeglycyl-radical enzyme activating protein family8e-53207
NC_009454:2502724:253056025305602531471912Pelotomaculum thermopropionicum SI, complete genomepyruvate-formate lyase-activating enzyme5e-52204
NC_021182:4058873:406569240656924066615924Clostridium pasteurianum BC1, complete genomeglycyl-radical enzyme activator family protein5e-51201
NC_015573:2463123:250043325004332501374942Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomeglycyl-radical enzyme activating protein family5e-51201
NC_021182:4058873:406031340603134061218906Clostridium pasteurianum BC1, complete genomeglycyl-radical enzyme activator family protein2e-50199
NC_012108:481657:495044495044495952909Desulfobacterium autotrophicum HRM2, complete genomePflC19e-49194
NC_021182:966839:969602969602970534933Clostridium pasteurianum BC1, complete genomeglycyl-radical enzyme activator family protein3e-48192
NC_016048:3856665:387205538720553872969915Oscillibacter valericigenes Sjm18-20, complete genomeglycyl-radical enzyme activating family protein5e-48191
NC_009615:919495:924724924724925629906Parabacteroides distasonis ATCC 8503 chromosome, complete genomepyruvate-formate lyase-activating enzyme9e-47187
NC_009438:212476:226933226933227853921Shewanella putrefaciens CN-32 chromosome, complete genomeglycyl-radical activating family protein2e-46186
NC_008750:450233:464493464493465413921Shewanella sp. W3-18-1, complete genomeglycyl-radical enzyme activating protein family2e-46186
NC_021184:657093:657093657093658031939Desulfotomaculum gibsoniae DSM 7213, complete genomeglycyl-radical enzyme activator family protein7e-46184
NC_008751:607209:624617624617625540924Desulfovibrio vulgaris subsp. vulgaris DP4, complete genomeglycyl-radical enzyme activating protein family6e-46184
NC_014624:2297000:230867423086742309594921Eubacterium limosum KIST612 chromosome, complete genomeputative pyruvate-formate lyase-activating enzyme3e-45182
NC_002937:2933000:293303029330302933953924Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completepyruvate formate-lyase 1 activating enzyme, putative5e-45181
NC_009089:1283000:131846813184681319370903Clostridium difficile 630, complete genomeglycerol dehydratase activator8e-43174
AP010958:922937:947234947234948133900Escherichia coli O103:H2 str. 12009 DNA, complete genomepredicted pyruvate formate lyase activating enzyme8e-43174
NC_013353:922937:947234947234948133900Escherichia coli O103:H2 str. 12009, complete genomepyruvate formate lyase activating enzyme8e-43174
NC_013364:928486:951505951505952404900Escherichia coli O111:H- str. 11128, complete genomeputative pyruvate formate lyase activating enzyme8e-43174
NC_021184:657093:670474670474671469996Desulfotomaculum gibsoniae DSM 7213, complete genomeglycyl-radical enzyme activator family protein1e-42173
NC_015424:2917817:293754229375422938438897Aeromonas veronii B565 chromosome, complete genomepyruvate formate-lyase 2-activating enzyme5e-40165
NC_015577:3621777:364344236434423644344903Treponema azotonutricium ZAS-9 chromosome, complete genomepyruvate formate-lyase-activating enzyme9e-39160
NC_014328:2872721:287420728742072875118912Clostridium ljungdahlii ATCC 49587 chromosome, complete genomepyruvate formate-lyase activating enzyme2e-38159
NC_014393:1421122:142540714254071426303897Clostridium cellulovorans 743B chromosome, complete genomeRadical SAM domain-containing protein3e-36152
NC_014363:114239:141718141718142665948Olsenella uli DSM 7084 chromosome, complete genomeglycyl-radical enzyme activating protein family3e-36152
NC_010001:1488000:149196114919611492752792Clostridium phytofermentans ISDg, complete genomeglycyl-radical enzyme activating protein family7e-34144
NC_016938:193000:211219211219211995777Melissococcus plutonius DAT561 chromosome 1, complete genomepyruvate formate-lyase activating enzyme5e-33141
NC_012470:2021316:202131620213162022089774Streptococcus equi subsp. zooepidemicus, complete genomepyruvate formate-lyase activating enzyme2e-32140
NC_013517:2055071:205983920598392060660822Sebaldella termitidis ATCC 33386, complete genomeglycyl-radical enzyme activating protein family3e-31135
NC_015555:49842:739707397074698729Thermoanaerobacterium xylanolyticum LX-11 chromosome, completepyruvate formate-lyase activating enzyme5e-27122
NC_014933:2240000:224205322420532242778726Bacteroides helcogenes P 36-108 chromosome, complete genomepyruvate formate-lyase activating enzyme1e-24114
NC_013410:1285857:129149512914951292271777Fibrobacter succinogenes subsp. succinogenes S85 chromosome,pyruvate formate-lyase activating enzyme2e-24113
NC_014410:51711:749047490475632729Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,pyruvate formate-lyase activating enzyme4e-23108
NC_019970:35985:607916079161519729Thermoanaerobacterium thermosaccharolyticum M0795, complete genomepyruvate formate-lyase 1-activating enzyme8e-23107
NC_011094:1050700:106119810611981061995798Salmonella enterica subsp. enterica serovar Schwarzengrund strpyruvate formate lyase-activating enzyme 16e-22105
NC_009012:1901492:190757919075791908421843Clostridium thermocellum ATCC 27405, complete genomeRadical SAM7e-22104
NC_009801:995396:9998659998651000662798Escherichia coli E24377A, complete genomepyruvate formate-lyase 1-activating enzyme2e-21103
NC_015275:1223088:124302112430211243746726Clostridium lentocellum DSM 5427 chromosome, complete genomepyruvate formate-lyase activating enzyme9e-21101
NC_009831:2045811:204581120458112046551741Shewanella sediminis HAW-EB3, complete genome(Formate-C-acetyltransferase)-activating enzyme2e-20100
NC_014376:317312:336200336200336973774Clostridium saccharolyticum WM1 chromosome, complete genomepyruvate formate-lyase activating enzyme2e-2099.8
NC_015460:418826:434556434556435296741Gallibacterium anatis UMN179 chromosome, complete genomepyruvate formate lyase-activating enzyme 13e-2099.4
NC_004347:3028000:304450830445083045248741Shewanella oneidensis MR-1, complete genomepyruvate formate-lyase 1 activating enzyme3e-2099.4
NC_016818:1605918:160938716093871610184798Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completepyruvate formate-lyase activating enzyme1e-1997.8
NC_015061:1598920:160241216024121603209798Rahnella sp. Y9602 chromosome, complete genomepyruvate formate-lyase activating enzyme1e-1997.8
NC_017047:1551836:155532815553281556068741Rahnella aquatilis HX2 chromosome, complete genomepyruvate formate lyase-activating enzyme 11e-1997.4
NC_006448:1451729:145231514523151453115801Streptococcus thermophilus LMG 18311, complete genomepyruvate-formate lyase activating enzyme1e-1997.4
NC_016627:1960097:197152619715261972368843Clostridium clariflavum DSM 19732 chromosome, complete genomeglycine radical enzyme activase, YjjW family2e-1997.1
NC_010001:3421710:344193634419363442688753Clostridium phytofermentans ISDg, complete genomepyruvate formate-lyase activating enzyme2e-1893.6
NC_007712:1601499:162391816239181624658741Sodalis glossinidius str. 'morsitans', complete genomepyruvate formate-lyase 1 activating enzyme1e-1790.5
NC_010159:1668795:167164316716431672377735Yersinia pestis Angola, complete genomepyruvate formate-lyase 1-activating enzyme5e-1788.6
NC_014033:1808782:183079218307921831628837Prevotella ruminicola 23 chromosome, complete genomeradical SAM domain-containing protein9e-1581.3
NC_014614:2500301:252580225258022526560759Clostridium sticklandii, complete genomepyruvate formate lyase activating enzyme 11e-1480.9
NC_004603:1464000:146656414665641467445882Vibrio parahaemolyticus RIMD 2210633 chromosome I, completepyruvate formate lyase activating enzyme3e-1479.7
NC_008618:1206157:122747812274781228356879Bifidobacterium adolescentis ATCC 15703, complete genomepyruvate formate-lyase 1 activating enzyme2e-1376.6
NC_017343:224777:227049227049227804756Staphylococcus aureus subsp. aureus ECT-R 2, complete genomepyruvate formate-lyase activating enzyme3e-1376.3
NC_004461:205068:205068205068205823756Staphylococcus epidermidis ATCC 12228, complete genomeformate acetyltransferase activating enzyme1e-1274.3
NC_017297:2288000:230447523044752304627153Clostridium botulinum F str. 230613 chromosome, complete genome1e-1274.3
NC_015709:1769806:179812517981251798919795Zymomonas mobilis subsp. pomaceae ATCC 29192 chromosome, completepyruvate formate-lyase activating enzyme6e-1272
NC_014618:4010689:404083540408354041698864Enterobacter cloacae SCF1 chromosome, complete genomeradical SAM protein1e-1170.5
NC_013716:5141269:516390851639085164771864Citrobacter rodentium ICC168, complete genomeradical SAM superfamily protein2e-1169.7
NC_013093:2633000:267457826745782675423846Actinosynnema mirum DSM 43827, complete genomepyruvate formate-lyase activating enzyme5e-1168.9
NC_013714:1521404:154305415430541543935882Bifidobacterium dentium Bd1, complete genomepflA1 Pyruvate formate-lyase activating enzyme2e-1066.6
NC_018750:3315309:332659433265943327406813Streptomyces venezuelae ATCC 10712, complete genomePyruvate formate-lyase activating enzyme3e-1066.2
NC_015500:311845:324489324489325265777Treponema brennaborense DSM 12168 chromosome, complete genome(Formate-C-acetyltransferase)-activating enzyme6e-1065.1
NC_015578:423000:423018423018423869852Treponema primitia ZAS-2 chromosome, complete genomeradical SAM2e-0963.5
NC_016605:233087:236623236623237444822Pediococcus claussenii ATCC BAA-344 chromosome, complete genomepyruvate formate-lyase activating enzyme3e-0962.8
NC_000909:446364:455930455930456421492Methanocaldococcus jannaschii DSM 2661, complete genomepolyferredoxin (mvhB)3e-0652.8