Pre_GI: BLASTP Hits

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Query: NC_009699:2287893:2301999 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 2301999, End: 2302715, Length: 717

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:2171151:218164721816472182375729Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein2e-113408
NC_009697:2173000:218142821814282182156729Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein2e-113408
NC_009495:2244774:225278622527862253514729Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein2e-113408
NC_012563:2384500:239619023961902396918729Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein9e-112402
NC_012658:2295536:231015623101562310884729Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein6e-111399
NC_017297:2288000:230222423022242302829606Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-96352
NC_004557:1553000:156075415607541561422669Clostridium tetani E88, complete genomehypothetical protein3e-76284
NC_010723:1465097:147799714779971478665669Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein6e-53207
NC_010674:1496500:150778415077841508452669Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein5e-51201
NC_014328:4316008:432896843289684329738771Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative ethanolamine utilization cobalamin adenosyltransferase2e-46186
NC_014328:1286407:129198012919801292753774Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative ethanolamine utilization cobalamin adenosyltransferase6e-45180
NC_009922:2556033:257057325705732571262690Alkaliphilus oremlandii OhILAs, complete genomeconserved hypothetical protein1e-38159
NC_010001:1745089:176098117609811761616636Clostridium phytofermentans ISDg, complete genomehypothetical protein3e-29128
NC_016584:5625975:563775656377565638424669Desulfosporosinus orientis DSM 765 chromosome, complete genomeethanolamine utilization cobalamin adenosyltransferase1e-22106
NC_009633:3933941:394725939472593947897639Alkaliphilus metalliredigens QYMF chromosome, complete genomehypothetical protein5e-1994.7