Pre_GI: BLASTP Hits

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Query: NC_009699:1698951:1718197 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 1718197, End: 1718556, Length: 360

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:1700000:171833017183301718689360Clostridium botulinum F str. 230613 chromosome, complete genomeputative iron-dependent repressor6e-63238
NC_012658:1658505:167473416747341675096363Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative iron-dependent repressor3e-61233
NC_015385:456000:476559476559476933375Treponema succinifaciens DSM 2489 chromosome, complete genomeiron (metal) dependent repressor, DtxR family2e-24110
NC_010001:1488000:150772215077221508087366Clostridium phytofermentans ISDg, complete genomeiron (metal) dependent repressor, DtxR family5e-24109
NC_015172:1471501:150546215054621505839378Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeiron (metal) dependent repressor, DtxR family1e-1788.6
NC_013410:2037840:205849220584922058926435Fibrobacter succinogenes subsp. succinogenes S85 chromosome,DtxR family iron (metal) dependent repressor2e-1787.8
NC_012883:104987:122828122828123253426Thermococcus sibiricus MM 739, complete genomeManganese-dependent transcription regulator4e-1786.7
NC_008554:4586543:461032446103244610857534Syntrophobacter fumaroxidans MPOB, complete genomeiron (metal) dependent repressor, DtxR family6e-1786.3
NC_013165:2240377:224037722403772240811435Slackia heliotrinireducens DSM 20476, complete genomeMn-dependent transcriptional regulator8e-1682.4
NC_017243:1041917:104191710419171042333417Brachyspira intermedia PWS/A chromosome, complete genomeiron dependend repressor4e-1580.1
NC_012471:1197534:123296812329681233348381Streptococcus equi subsp. equi 4047, complete genomeiron-dependent repressor protein8e-1579
NC_014363:114239:156802156802157224423Olsenella uli DSM 7084 chromosome, complete genomeiron (metal) dependent repressor, DtxR family3e-1477.4
NC_002936:67896:923739237393089717Dehalococcoides ethenogenes 195, complete genomeiron dependent repressor, putative5e-1476.3
NC_015499:1790186:179550217955021796221720Thermodesulfobium narugense DSM 14796 chromosome, complete genomeiron (metal) dependent repressor, DtxR family5e-1476.3
NC_013204:1759985:177898117789811779364384Eggerthella lenta DSM 2243, complete genomeiron (metal) dependent repressor, DtxR family2e-1374.7
NC_003552:4277937:427936842793684279850483Methanosarcina acetivorans C2A, complete genomehypothetical protein2e-1271.2
NC_013203:1447340:146155614615561461984429Atopobium parvulum DSM 20469, complete genomeiron (metal) dependent repressor, DtxR family3e-1270.5
NC_010003:605961:624080624080624751672Petrotoga mobilis SJ95, complete genomeiron (metal) dependent repressor, DtxR family7e-1269.3
NC_015574:806762:820865820865821323459Methanobacterium sp. SWAN-1 chromosome, complete genomeiron (metal) dependent repressor, DtxR family3e-1167.4
NC_009776:617532:633366633366633743378Ignicoccus hospitalis KIN4/I, complete genomeiron dependent repressor1e-1065.1
NC_013895:1332832:1339746133974613409031158Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, completeiron dependent repressor, N-terminal DNA binding domain protein1e-1065.1
NC_014376:3593500:360909336090933609512420Clostridium saccharolyticum WM1 chromosome, complete genomeiron dependent repressor2e-1064.3
NC_006138:3355028:335673633567363357242507Desulfotalea psychrophila LSv54, complete genomeiron-dependent repressor3e-1063.9
NC_003551:154883:170934170934171410477Methanopyrus kandleri AV19, complete genomeMn-dependent transcriptional regulator6e-1062.8
NC_016048:2873669:288808128880812888506426Oscillibacter valericigenes Sjm18-20, complete genomeputative transcriptional regulator7e-1062.8
NC_015683:1467000:146716514671651467845681Corynebacterium ulcerans BR-AD22 chromosome, complete genomeDtxR family transcription regulator8e-1062.4
NC_017317:1463466:146346614634661464146681Corynebacterium ulcerans 809 chromosome, complete genomeDtxR-family transcription regulator8e-1062.4
NC_013364:928486:933261933261933728468Escherichia coli O111:H- str. 11128, complete genomeDNA-binding transcriptional regulator1e-0962
NC_013353:922937:927712927712928179468Escherichia coli O103:H2 str. 12009, complete genomeDNA-binding transcriptional regulator of mntH1e-0962
AP010958:922937:927712927712928179468Escherichia coli O103:H2 str. 12009 DNA, complete genomeDNA-binding transcriptional regulator of mntH1e-0962
NC_014329:1328949:132894913289491329629681Corynebacterium pseudotuberculosis FRC41 chromosome, completeDtxR family transcriptional regulator1e-0961.6
NC_016781:1327516:132876913287691329449681Corynebacterium pseudotuberculosis 3/99-5 chromosome, completediphtheria toxin repressor1e-0961.6
NC_016932:1309644:131365413136541314334681Corynebacterium pseudotuberculosis 316 chromosome, complete genomeDiphtheria toxin repressor1e-0961.6
NC_017031:1328500:132875513287551329435681Corynebacterium pseudotuberculosis P54B96 chromosome, completeDiphtheria toxin repressor1e-0961.6
NC_017300:1326331:132633113263311327011681Corynebacterium pseudotuberculosis 1002 chromosome, completeDiphtheria toxin repressor1e-0961.6
NC_017301:1328500:132863613286361329316681Corynebacterium pseudotuberculosis C231 chromosome, completeDiphtheria toxin repressor1e-0961.6
NC_017303:1328777:132877713287771329457681Corynebacterium pseudotuberculosis I19 chromosome, complete genomeDiphtheria toxin repressor1e-0961.6
NC_017305:1326351:132635113263511327031681Corynebacterium pseudotuberculosis PAT10 chromosome, completeDiphtheria toxin repressor1e-0961.6
NC_008536:2775517:279104327910432791699657Solibacter usitatus Ellin6076, complete genomeiron (metal) dependent repressor, DtxR family2e-0961.2
NC_016787:1350676:141125514112551411935681Corynebacterium diphtheriae HC03 chromosome, complete genomediphtheria toxin repressor4e-0960.1
NC_016786:1359064:141994214199421420622681Corynebacterium diphtheriae HC01 chromosome, complete genomediphtheria toxin repressor4e-0960.1
NC_016785:1357500:139782913978291398509681Corynebacterium diphtheriae CDCE 8392 chromosome, complete genomediphtheria toxin repressor4e-0960.1
NC_016783:1397975:144026914402691440949681Corynebacterium diphtheriae INCA 402 chromosome, complete genomediphtheria toxin repressor4e-0960.1
NC_016782:1385800:141967714196771420357681Corynebacterium diphtheriae 241 chromosome, complete genomediphtheria toxin repressor4e-0960.1
NC_002935:1378566:143133514313351432015681Corynebacterium diphtheriae NCTC 13129, complete genomediphtheria toxin repressor4e-0960.1
NC_016788:1376000:141472014147201415400681Corynebacterium diphtheriae HC04 chromosome, complete genomediphtheria toxin repressor4e-0960.1
NC_016789:1432000:146518114651811465861681Corynebacterium diphtheriae PW8 chromosome, complete genomediphtheria toxin repressor4e-0960.1
NC_016790:1345638:138732213873221388002681Corynebacterium diphtheriae VA01 chromosome, complete genomediphtheria toxin repressor4e-0960.1
NC_016800:1411000:144781814478181448498681Corynebacterium diphtheriae BH8 chromosome, complete genomediphtheria toxin repressor4e-0960.1
NC_016801:1422500:146147114614711462151681Corynebacterium diphtheriae C7 (beta) chromosome, complete genomediphtheria toxin repressor4e-0960.1
NC_016802:1317365:140446814044681405148681Corynebacterium diphtheriae HC02 chromosome, complete genomediphtheria toxin repressor4e-0960.1
NC_014378:4428:204002040020885486Acetohalobium arabaticum DSM 5501 chromosome, complete genomeiron (metal) dependent repressor, DtxR family4e-0960.1
NC_016799:1439000:147148714714871472167681Corynebacterium diphtheriae 31A chromosome, complete genomediphtheria toxin repressor4e-0960.1
NC_018720:357716:362611362611363312702Bifidobacterium asteroides PRL2011 chromosome, complete genomeDtxR family transcriptional regulator6e-0856.2
NC_009485:1604942:164018716401871640612426Bradyrhizobium sp. BTAi1 chromosome, complete genomemanganese transport regulator MntR8e-0855.8
NC_009253:2927802:294803529480352948469435Desulfotomaculum reducens MI-1 chromosome, complete genomeiron dependent repressor2e-0754.7
NC_014550:615609:622233622233622928696Arthrobacter arilaitensis Re117, complete genomeiron-dependent repressor IdeR2e-0754.3
NC_008698:903759:922126922126922572447Thermofilum pendens Hrk 5, complete genomeiron dependent repressor3e-0753.9
NC_015555:211935:229660229660230130471Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeiron (metal) dependent repressor, DtxR family4e-0753.5
NC_014011:1264165:126849512684951269133639Aminobacterium colombiense DSM 12261 chromosome, complete genomeiron (metal) dependent repressor, DtxR family6e-0752.8
NC_014151:813755:842050842050842739690Cellulomonas flavigena DSM 20109 chromosome, complete genomeiron (metal) dependent repressor, DtxR family3e-0650.4
NC_014532:2989185:300928430092843009694411Halomonas elongata DSM 2581, complete genomemanganese transport regulator MntR7e-0649.3
NC_013741:27353:417484174842329582Archaeoglobus profundus DSM 5631, complete genomeiron (metal) dependent repressor, DtxR family9e-0648.9
NC_014408:1193239:121558712155871215982396Methanothermobacter marburgensis str. Marburg chromosome, completemetal-dependent transcriptional regulator1e-0548.9