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Query: NC_009699:1698951:1709689 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 1709689, End: 1710519, Length: 831

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:1700000:170982017098201710650831Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein4e-159560
NC_012658:1658505:166887916688791669709831Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein1e-158558
NC_014328:2518081:252199425219942522824831Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein2e-145514
NC_008593:1859861:187885718788571879687831Clostridium novyi NT, complete genomehypothetical protein2e-139494
NC_013406:5954472:595447259544725955302831Paenibacillus sp. Y412MC10 chromosome, complete genomeTIM-barrel signal transduction protein2e-129461
NC_014298:310964:329305329305330138834Halalkalicoccus jeotgali B3 plasmid 1, complete sequenceTIM-barrel signal transduction protein5e-99360
NC_019974:3013338:304235130423513043184834Natronococcus occultus SP4, complete genomeputative TIM-barrel enzyme, possibly a dioxygenase2e-97355
NC_012658:1658505:1666264166626416674811218Clostridium botulinum Ba4 str. 657 chromosome, complete genomeAraC family transcriptional regulator1e-63243
NC_009699:1698951:1707074170707417082911218Clostridium botulinum F str. Langeland chromosome, complete genomeAraC family transcriptional regulator1e-63243
NC_017297:1700000:1707235170723517084221188Clostridium botulinum F str. 230613 chromosome, complete genomeAraC family transcriptional regulator9e-64243
NC_006085:925604:947633947633948139507Propionibacterium acnes KPA171202, complete genometranscriptional regulator1e-62239
NC_013406:5954472:5956693595669359579341242Paenibacillus sp. Y412MC10 chromosome, complete genomeAraC family transcriptional regulator2e-59229
NC_014328:2518081:2524207252420725254541248Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative transcriptional regulator1e-58226
NC_008593:1859861:1881113188111318822881176Clostridium novyi NT, complete genometranscriptional regulator, araC family protein6e-57221
NC_006085:925604:948169948169948480312Propionibacterium acnes KPA171202, complete genomeconserved protein, putative Y4OV fragment1e-37156