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Query: NC_009699:1698951:1708456 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 1708456, End: 1709664, Length: 1209

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:1700000:1708587170858717097951209Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein0780
NC_012658:1658505:1667646166764616688541209Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein0770
NC_014328:2518081:2522853252285325240611209Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein0648
NC_013406:5954472:5955352595535259565631212Paenibacillus sp. Y412MC10 chromosome, complete genomehypothetical protein9e-160563
NC_008593:1859861:1879710187971018809211212Clostridium novyi NT, complete genomeHypothetical UPF0261 protein3e-155548
NC_019974:3013338:3041141304114130423491209Natronococcus occultus SP4, complete genomehypothetical protein7e-110397
NC_014298:310964:3280773280773293031227Halalkalicoccus jeotgali B3 plasmid 1, complete sequencehypothetical protein2e-108392
NC_004547:1062410:1080117108011710813251209Erwinia carotovora subsp. atroseptica SCRI1043, complete genomehypothetical protein6e-76284
NC_017955:2327500:2344452234445223457381287Modestobacter marinus, complete genomehypothetical protein1e-65250
NC_012883:1462000:1478525147852514799551431Thermococcus sibiricus MM 739, complete genomehypothetical protein2e-51203
NC_007517:2342607:2369593236959323708491257Geobacter metallireducens GS-15, complete genomehypothetical protein2e-44180
NC_006085:925604:949031949031949723693Propionibacterium acnes KPA171202, complete genomeconserved protein, putative Y4OU fragment1e-35150
NC_006085:925604:948738948738948926189Propionibacterium acnes KPA171202, complete genomeconserved protein, putative Y4OU fragment4e-1066.2