Pre_GI: BLASTP Hits

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Query: NC_009699:1698951:1704744 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 1704744, End: 1705286, Length: 543

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:1700000:170487417048741705416543Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein5e-77286
NC_012658:1658505:166392716639271664469543Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein6e-72269
NC_014328:2990790:299283429928342993361528Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein3e-24110
NC_014150:648868:650743650743651300558Brachyspira murdochii DSM 12563 chromosome, complete genomeflavodoxin/nitric oxide synthase4e-22103
NC_017243:1901898:190677719067771907334558Brachyspira intermedia PWS/A chromosome, complete genomeflavodoxin4e-22103
NC_015738:220000:227440227440227979540Eggerthella sp. YY7918, complete genomehypothetical protein2e-0962