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Query: NC_009698:3647955:3665820 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 3665820, End: 3666107, Length: 288

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:3878540:389372438937243894011288Clostridium botulinum F str. 230613 chromosome, complete genomestage V sporulation protein G9e-49191
NC_009697:3753527:376871037687103768997288Clostridium botulinum A str. ATCC 19397 chromosome, completeregulatory protein SpoVG9e-49191
NC_010516:3845942:386385838638583864145288Clostridium botulinum B1 str. Okra, complete genomestage V sporulation protein G9e-49191
NC_009633:168266:171978171978172274297Alkaliphilus metalliredigens QYMF chromosome, complete genomeregulatory protein SpoVG4e-33139
NC_014624:3538094:354477735447773545103327Eubacterium limosum KIST612 chromosome, complete genomeSpoVG family protein1e-30131
NC_012121:139741:149479149479149802324Staphylococcus carnosus subsp. carnosus TM300, complete genomestage V sporulation protein G8e-28122
NC_014828:2605798:262810426281042628379276Ethanoligenens harbinense YUAN-3 chromosome, complete genomeSpoVG family protein4e-1993.2
NC_008710:819389:830734830734831024291Borrelia turicatae 91E135, complete genomestage V sporulation protein G7e-1992.4
NC_013741:838243:840581840581840838258Archaeoglobus profundus DSM 5631, complete genomeSpoVG family protein2e-1684.7
NC_014654:2180994:220625822062582206524267Halanaerobium sp. 'sapolanicus' chromosome, complete genomeSpoVG family protein2e-1684.3
NC_019903:1312843:132564913256491326053405Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,hypothetical protein2e-1580.9
NC_019903:1345585:136120513612051361621417Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,hypothetical protein3e-1580.9
NC_019903:1745849:175825517582551758674420Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,hypothetical protein3e-1580.1
NC_014376:3064787:306983930698393070198360Clostridium saccharolyticum WM1 chromosome, complete genomeSpoVG family protein5e-1579.7
NC_010337:565730:587772587772588158387Heliobacterium modesticaldum Ice1, complete genomespovg septation protein6e-1579.3
NC_021184:3571014:357866635786663579073408Desulfotomaculum gibsoniae DSM 7213, complete genomeuncharacterized protein, involved in the regulation of septum location1e-1478.6
NC_012781:700226:717362717362718003642Eubacterium rectale ATCC 33656, complete genomestage V sporulation protein G6e-1372.8
NC_012781:2552723:258075625807562581397642Eubacterium rectale ATCC 33656, complete genomestage V sporulation protein G6e-1372.8
NC_013768:1830419:184723218472321847570339Listeria monocytogenes 08-5923, complete genomehypothetical protein7e-1165.9
NC_013766:1859634:188050118805011880839339Listeria monocytogenes 08-5578 chromosome, complete genomehypothetical protein7e-1165.9
NC_009706:3882500:393592339359233936249327Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein9e-1165.5
NC_011837:3814000:386742638674263867752327Clostridium kluyveri NBRC 12016, complete genomehypothetical protein9e-1165.5
NC_015977:3424178:348877634887763489459684Roseburia hominis A2-183 chromosome, complete genomeSpoVG family protein3e-1063.9
NC_011837:238160:255446255446255940495Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-0753.9
NC_009706:238160:255446255446255940495Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein3e-0753.9
NC_012440:1215838:121790012179001218175276Persephonella marina EX-H1, complete genomeputative septation protein spoVG6e-0752.8