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Query: NC_009698:3647955:3648035 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 3648035, End: 3648123, Length: 89

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:3839575:38775963877596387768489Clostridium botulinum F str. Langeland chromosome, complete genometRNA-Leu6e-1062.8
NC_009699:3839575:38773153877315387740389Clostridium botulinum F str. Langeland chromosome, complete genometRNA-Leu6e-1062.8
NC_008262:784878:79983179983179991989Clostridium perfringens SM101, complete genometRNA-Leu1e-0755.5
NC_008262:2649289:26986812698681269876989Clostridium perfringens SM101, complete genometRNA-Leu1e-0755.5
NC_003366:842000:85702885702885711386Clostridium perfringens str. 13, complete genome7e-0752.8
NC_009922:1917271:19242391924239192432789Alkaliphilus oremlandii OhILAs, complete genometRNA-Leu8e-0752.4
NC_009922:2590317:26047922604792260488089Alkaliphilus oremlandii OhILAs, complete genometRNA-Leu8e-0752.4
NC_009922:2590317:25981522598152259824089Alkaliphilus oremlandii OhILAs, complete genometRNA-Leu8e-0752.4
NC_010001:434803:45210745210745219286Clostridium phytofermentans ISDg, complete genometRNA-Leu1e-0651.6
NC_008262:2649289:26981462698146269823489Clostridium perfringens SM101, complete genometRNA-Leu3e-0650.8
NC_008262:2649289:26984142698414269850289Clostridium perfringens SM101, complete genometRNA-Leu3e-0650.8
NC_010723:173280:17745317745317754189Clostridium botulinum E3 str. Alaska E43, complete genometRNA-Leu3e-0650.4
NC_014614:2500301:25103622510362251045089Clostridium sticklandii, complete genometRNA-Leu6e-0649.7
NC_007929:210088:22326522326522335086Lactobacillus salivarius subsp. salivarius UCC118, complete genometRNA-Leu9e-0648.9
NC_004668:241352:25380825380825389386Enterococcus faecalis V583, complete genometRNA-Leu9e-0648.9
NC_004668:3156247:31646103164610316469586Enterococcus faecalis V583, complete genometRNA-Leu9e-0648.9
NC_007929:473500:48562448562448570986Lactobacillus salivarius subsp. salivarius UCC118, complete genometRNA-Leu9e-0648.9