Pre_GI: BLASTP Hits

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Query: NC_009698:3553365:3555511 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 3555511, End: 3556218, Length: 708

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011837:238160:272494272494273207714Clostridium kluyveri NBRC 12016, complete genomehypothetical protein5e-57220
NC_009706:238160:272494272494273207714Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein5e-57220
NC_014328:4387303:440894644089464409641696Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeTPR-repeat-containing protein7e-57220
NC_015425:2389400:238940023894002390011612Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein3e-47188
NC_011729:1496848:1496848149684815006783831Cyanothece sp. PCC 7424 chromosome, complete genomehypothetical protein3e-1065.5
NC_008312:7099417:7112497711249771138551359Trichodesmium erythraeum IMS101, complete genomeTPR repeat4e-1065.1
NC_012225:2834642:2844286284428628467392454Brachyspira hyodysenteriae WA1, complete genomeputative TPR domain-containing protein8e-1063.9
NC_014150:2617072:2626326262632626285782253Brachyspira murdochii DSM 12563 chromosome, complete genomeTPR repeat-containing protein4e-0961.6
NC_009925:647752:6545326545326562021671Acaryochloris marina MBIC11017, complete genomepeptidase, M50 family7e-0960.8
NC_000916:31459:5142651426525651140Methanothermobacter thermautotrophicus str. Delta H, completeO-linked GlcNAc transferase1e-0860.5
NC_011894:7421867:7434437743443774374032967Methylobacterium nodulans ORS 2060, complete genomepeptidase C14 caspase catalytic subunit p201e-0860.1
NC_014408:1018448:1026328102632810275481221Methanothermobacter marburgensis str. Marburg chromosome, completetetratricopeptide repeat domain-containing protein2e-0859.7
NC_018607:895204:910760910760911716957Brachyspira pilosicoli B2904 chromosome, complete genomehypothetical protein7e-0857.4
NC_012225:2834642:2847047284704728484081362Brachyspira hyodysenteriae WA1, complete genomeTPR domain-containing protein1e-0757
NC_019977:1245894:1262204126220412649452742Methanomethylovorans hollandica DSM 15978, complete genomeputative endonuclease related to Holliday junction resolvase2e-0756.2
NC_013156:573037:593217593217594089873Methanocaldococcus fervens AG86, complete genomeTetratricopeptide TPR_2 repeat protein4e-0755.1
NC_013790:2337000:235802023580202358601582Methanobrevibacter ruminantium M1 chromosome, complete genomeTPR repeat-containing protein6e-0754.7
NC_011894:3029964:3038773303877330411272355Methylobacterium nodulans ORS 2060, complete genomepeptidase C14 caspase catalytic subunit p206e-0754.7
NC_014150:2617072:2628740262874026297981059Brachyspira murdochii DSM 12563 chromosome, complete genomeTPR repeat-containing protein5e-0754.7
NC_013926:511674:5191135191135209031791Aciduliprofundum boonei T469 chromosome, complete genomeTPR repeat-containing protein5e-0754.7
NC_010793:1158279:1170884117088411720291146Orientia tsutsugamushi str. Ikeda, complete genomeTPR repeat-containing protein 01_078e-0754.3
NC_010793:1508974:1515258151525815164031146Orientia tsutsugamushi str. Ikeda, complete genomeTPR repeat-containing protein 01_098e-0754.3
NC_015416:223968:241305241305242090786Methanosaeta concilii GP-6 chromosome, complete genomeTPR-repeat-containing protein7e-0754.3
NC_014150:1902241:1902241190224119045172277Brachyspira murdochii DSM 12563 chromosome, complete genomeTetratricopeptide TPR_2 repeat protein7e-0754.3
NC_011894:2503639:2517451251745125199072457Methylobacterium nodulans ORS 2060, complete genomepeptidase C14 caspase catalytic subunit p206e-0754.3
NC_014150:2617072:2624435262443526262881854Brachyspira murdochii DSM 12563 chromosome, complete genomeTPR repeat-containing protein9e-0753.9
NC_015416:1478775:1495940149594014972111272Methanosaeta concilii GP-6 chromosome, complete genomehypothetical protein9e-0753.9
NC_011894:6295807:6299486629948663026563171Methylobacterium nodulans ORS 2060, complete genomepeptidase C14 caspase catalytic subunit p201e-0653.5
NC_005071:1903581:1911797191179719138722076Prochlorococcus marinus str. MIT 9313, complete genomeTPR repeat1e-0653.5
NC_005071:1903581:1913984191398419164732490Prochlorococcus marinus str. MIT 9313, complete genomeTPR repeat:HAT (Half-A-TPR) repeat2e-0653.1
NC_011894:2549076:2561841256184125649093069Methylobacterium nodulans ORS 2060, complete genomepeptidase C14 caspase catalytic subunit p202e-0652.8
NC_009488:681000:694297694297695271975Orientia tsutsugamushi str. Boryong, complete genomehypothetical protein2e-0652.8
NC_005071:288922:3365573365573397303174Prochlorococcus marinus str. MIT 9313, complete genomeTPR repeat2e-0652.8
NC_008820:2512518:2518732251873225201201389Prochlorococcus marinus str. MIT 9303, complete genomehypothetical protein3e-0652.4
NC_010793:668500:684528684528685319792Orientia tsutsugamushi str. Ikeda, complete genomeTPR repeat-containing protein 053e-0652
NC_019908:2183215:2187826218782621906032778Brachyspira pilosicoli P43/6/78 chromosome, complete genomehypothetical protein3e-0652
NC_015416:2926236:294481129448112945602792Methanosaeta concilii GP-6 chromosome, complete genomeTPR-repeat-containing protein3e-0652
NC_012440:1841315:1861196186119618622331038Persephonella marina EX-H1, complete genomeTPR Domain containing protein4e-0651.6
NC_014330:505412:5417245417245435741851Brachyspira pilosicoli 95/1000 chromosome, complete genomehypothetical protein6e-0651.2
NC_000909:858840:869478869478870434957Methanocaldococcus jannaschii DSM 2661, complete genometransformation sensitive protein6e-0651.2
NC_010793:416849:4226024226024237411140Orientia tsutsugamushi str. Ikeda, complete genomeTPR repeat-containing protein 01_036e-0651.2
NC_010511:637214:6417186417186448883171Methylobacterium sp. 4-46 chromosome, complete genomepeptidase C14 caspase catalytic subunit p205e-0651.2
NC_019908:121178:1211781211781230281851Brachyspira pilosicoli P43/6/78 chromosome, complete genomehypothetical protein7e-0650.8
NC_010793:1811401:1862337186233718634761140Orientia tsutsugamushi str. Ikeda, complete genomeTPR repeat-containing protein 01_108e-0650.8
NC_000916:31459:4322743227444381212Methanothermobacter thermautotrophicus str. Delta H, completeO-linked GlcNAc transferase8e-0650.8
NC_014408:1455851:1466636146663614677961161Methanothermobacter marburgensis str. Marburg chromosome, completetetratricopeptide repeat domain-containing protein9e-0650.4