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Query: NC_009698:3526359:3537698 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 3537698, End: 3538360, Length: 663

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:3629250:364058936405893641251663Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein1e-125448
NC_012658:3744000:375551637555163756178663Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein3e-125447
NC_017297:3752000:376604637660463766708663Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein5e-125446
NC_009699:3753599:376743237674323768094663Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein5e-125446
NC_010520:3753875:376516737651673765829663Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein7e-125446
NC_012563:3921859:393250439325043933166663Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein9e-125445
NC_010516:3724312:373565337356533736315663Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-124444
NC_014538:1942500:195073219507321951406675Thermoanaerobacter sp. X513 chromosome, complete genomehypothetical protein2e-53209
NC_015958:2206032:223131622313162231990675Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomehypothetical protein9e-53206
NC_009089:117980:158247158247158924678Clostridium difficile 630, complete genomeputative ATP/GTP-binding protein5e-48191
NC_015555:386000:392940392940393614675Thermoanaerobacterium xylanolyticum LX-11 chromosome, completehypothetical protein5e-48190
NC_013316:120759:153826153826154434609Clostridium difficile R20291, complete genomeputative ATP/GTP-binding protein6e-40163
NC_009616:99647:107486107486108130645Thermosipho melanesiensis BI429 chromosome, complete genomehypothetical protein1e-36152
NC_010003:1577934:158807315880731588753681Petrotoga mobilis SJ95, complete genomehypothetical protein3e-36151
NC_011653:331986:341062341062341706645Thermosipho africanus TCF52B, complete genomehypothetical protein2e-35148
NC_016751:142237:152217152217152885669Marinitoga piezophila KA3 chromosome, complete genomehypothetical protein3e-35148
NC_008346:36176:398783987840558681Syntrophomonas wolfei subsp. wolfei str. Goettingen, completehypothetical protein2e-2099.4
NC_010337:1188373:119238311923831193069687Heliobacterium modesticaldum Ice1, complete genomehypothetical protein1e-1790.1
NC_007503:1111457:116231111623111162982672Carboxydothermus hydrogenoformans Z-2901, complete genomehypothetical protein5e-1787.8
NC_015499:352934:367140367140367805666Thermodesulfobium narugense DSM 14796 chromosome, complete genomehypothetical protein5e-1684.7